PMID- 6327065
OWN - NLM
STAT- MEDLINE
DCOM- 19840723
LR  - 20190705
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 37
IP  - 2
DP  - 1984 Jun
TI  - A homologous protein-coding sequence in Drosophila homeotic genes and its 
      conservation in other metazoans.
PG  - 403-8
AB  - The homeotic genes of the bithorax complex (BX-C) and the Antennapedia complex 
      (ANT-C) of Drosophila appear to specify the developmental fate of segments or 
      parts of segments of the fly. We have previously reported weak DNA sequence 
      homology between 3' portions of the Antennapedia and fushi tarazu genes of the 
      ANT-C and the Ultrabithorax gene of the BX-C. Here we show that this DNA homology 
      (the homeo box) is due to a conserved protein-coding sequence present in these 
      three pattern-formation genes. Thus the functional homology between these 
      developmental controlling genes is reflected in a structural homology in their 
      gene products. The homeo box sequence is also present in a few copies in the 
      genomes of some other invertebrates, and is even conserved in vertebrate genomes, 
      including the human genome. Apparently at least a part of these developmental 
      switch genes from Drosophila is highly conserved during evolution, and might 
      perform an analogous function in many metazoans .
FAU - McGinnis, W
AU  - McGinnis W
FAU - Garber, R L
AU  - Garber RL
FAU - Wirz, J
AU  - Wirz J
FAU - Kuroiwa, A
AU  - Kuroiwa A
FAU - Gehring, W J
AU  - Gehring WJ
LA  - eng
SI  - GENBANK/K01947
SI  - GENBANK/K01948
SI  - GENBANK/K01959
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (Proteins)
RN  - EC 3.1.21.- (DNA Restriction Enzymes)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - *Biological Evolution
MH  - Cloning, Molecular
MH  - DNA Restriction Enzymes
MH  - Diptera/*genetics
MH  - Drosophila melanogaster/*genetics
MH  - *Genes
MH  - Proteins/*genetics
MH  - Species Specificity
EDAT- 1984/06/01 00:00
MHDA- 1984/06/01 00:01
CRDT- 1984/06/01 00:00
PHST- 1984/06/01 00:00 [pubmed]
PHST- 1984/06/01 00:01 [medline]
PHST- 1984/06/01 00:00 [entrez]
AID - 0092-8674(84)90370-2 [pii]
AID - 10.1016/0092-8674(84)90370-2 [doi]
PST - ppublish
SO  - Cell. 1984 Jun;37(2):403-8. doi: 10.1016/0092-8674(84)90370-2.