PMID- 6328312
OWN - NLM
STAT- MEDLINE
DCOM- 19840709
LR  - 20230120
IS  - 0028-0836 (Print)
IS  - 0028-0836 (Linking)
VI  - 309
IP  - 5967
DP  - 1984 May 31-Jun 6
TI  - Human epidermal growth factor receptor cDNA sequence and aberrant expression of 
      the amplified gene in A431 epidermoid carcinoma cells.
PG  - 418-25
AB  - The complete 1,210-amino acid sequence of the human epidermal growth factor (EGF) 
      receptor precursor, deduced from cDNA clones derived from placental and A431 
      carcinoma cells, reveals close similarity between the entire predicted v-erb-B 
      mRNA oncogene product and the receptor transmembrane and cytoplasmic domains. A 
      single transmembrane region of 23 amino acids separates the extracellular EGF 
      binding and cytoplasmic domains. The receptor gene is amplified and apparently 
      rearranged in A431 cells, generating a truncated 2.8-kilobase mRNA which encodes 
      only the extracellular EGF binding domain.
FAU - Ullrich, A
AU  - Ullrich A
FAU - Coussens, L
AU  - Coussens L
FAU - Hayflick, J S
AU  - Hayflick JS
FAU - Dull, T J
AU  - Dull TJ
FAU - Gray, A
AU  - Gray A
FAU - Tam, A W
AU  - Tam AW
FAU - Lee, J
AU  - Lee J
FAU - Yarden, Y
AU  - Yarden Y
FAU - Libermann, T A
AU  - Libermann TA
FAU - Schlessinger, J
AU  - Schlessinger J
AU  - et al.
LA  - eng
SI  - GENBANK/K01885
SI  - GENBANK/K02047
SI  - GENBANK/X00588
SI  - GENBANK/X00663
GR  - CA 25820/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - 0 (Peptide Fragments)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Cell Surface)
RN  - 62229-50-9 (Epidermal Growth Factor)
RN  - 9007-49-2 (DNA)
RN  - EC 2.7.10.1 (ErbB Receptors)
SB  - IM
MH  - Amino Acid Sequence
MH  - Base Sequence
MH  - Carcinoma, Squamous Cell
MH  - Cell Line
MH  - DNA/*metabolism
MH  - Epidermal Growth Factor/metabolism
MH  - ErbB Receptors
MH  - *Gene Amplification
MH  - *Genes
MH  - Humans
MH  - Nucleic Acid Hybridization
MH  - Peptide Fragments/analysis
MH  - RNA, Messenger/genetics
MH  - Receptors, Cell Surface/*genetics/metabolism
EDAT- 1984/05/06 00:00
MHDA- 1984/05/06 00:01
CRDT- 1984/05/06 00:00
PHST- 1984/05/06 00:00 [pubmed]
PHST- 1984/05/06 00:01 [medline]
PHST- 1984/05/06 00:00 [entrez]
AID - 10.1038/309418a0 [doi]
PST - ppublish
SO  - Nature. 1984 May 31-Jun 6;309(5967):418-25. doi: 10.1038/309418a0.