PMID- 6342645
OWN - NLM
STAT- MEDLINE
DCOM- 19830729
LR  - 20190515
IS  - 0007-0920 (Print)
IS  - 1532-1827 (Electronic)
IS  - 0007-0920 (Linking)
VI  - 47
IP  - 5
DP  - 1983 May
TI  - Cellular heterogeneity in tumours.
PG  - 589-94
AB  - Malignant tumours contain normal cells, descendants of transformed cells, and 
      conceivably also initiated cells which have taken some but not all of the steps 
      toward malignancy, and hybrid cells. Tumours are propagated by multiplication of 
      clonogenic cells, which are a subclass of the descendants of transformed cells. 
      The clonogenic cells of a tumour may differ in respect of morphology, karyotype, 
      metastatic capacity, sensitivity to cytotoxic drugs, expression of cell surface 
      antigens and hormone receptors, immunogenicity, sensitivity to the immune 
      reaction of the host, and other properties. Evidence (disputed by some) suggests 
      that selection of particular subpopulations plays a role in tumour metastasis and 
      recurrence. Heterogeneity may be due to pleoclonal origin, generation of 
      phenotypic diversity within a clone, or spontaneous hybridization and chromosome 
      loss. The possibility of interaction between different subpopulations must be 
      taken into account in discussing tumour cell population kinetics. Heterogeneity 
      also has important therapeutic implications and may help to explain the failure 
      of some therapeutic regimes and the success of others.
FAU - Woodruff, M F
AU  - Woodruff MF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Br J Cancer
JT  - British journal of cancer
JID - 0370635
SB  - IM
MH  - Animals
MH  - Cell Division
MH  - Cell Transformation, Neoplastic
MH  - Clone Cells
MH  - Humans
MH  - Hybrid Cells
MH  - Mutation
MH  - Neoplasm Metastasis
MH  - Neoplasms/genetics/*pathology/therapy
PMC - PMC2011371
EDAT- 1983/05/01 00:00
MHDA- 1983/05/01 00:01
CRDT- 1983/05/01 00:00
PHST- 1983/05/01 00:00 [pubmed]
PHST- 1983/05/01 00:01 [medline]
PHST- 1983/05/01 00:00 [entrez]
AID - 10.1038/bjc.1983.96 [doi]
PST - ppublish
SO  - Br J Cancer. 1983 May;47(5):589-94. doi: 10.1038/bjc.1983.96.