PMID- 6345555
OWN - NLM
STAT- MEDLINE
DCOM- 19830826
LR  - 20190508
IS  - 0021-9525 (Print)
IS  - 1540-8140 (Electronic)
IS  - 0021-9525 (Linking)
VI  - 97
IP  - 1
DP  - 1983 Jul
TI  - Immunohistochemical localization of a macrophage-specific antigen in developing 
      mouse retina: phagocytosis of dying neurons and differentiation of microglial 
      cells to form a regular array in the plexiform layers.
PG  - 253-7
AB  - In the developing mouse retina degenerating neurons can be observed initially in 
      the ganglion cell layer followed by a phase of cell death in the inner nuclear 
      layer. Using an immunohistochemical method to localize the mouse macrophage 
      specific antigen F4/80, we show that macrophages migrate from the vascular supply 
      overlying the developing retina and phagocytose the degenerating neurons. The 
      macrophages subsequently differentiate to become the microglia of the retina and 
      form a regularly spaced distribution across the retina in the inner and outer 
      plexiform layers. These experiments provide strong evidence for the mesodermal 
      origin of central nervous system microglia.
FAU - Hume, D A
AU  - Hume DA
FAU - Perry, V H
AU  - Perry VH
FAU - Gordon, S
AU  - Gordon S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Cell Biol
JT  - The Journal of cell biology
JID - 0375356
RN  - 0 (Antigens)
SB  - IM
MH  - Animals
MH  - Antigens/analysis
MH  - Cell Differentiation
MH  - Cell Survival
MH  - Immunoenzyme Techniques
MH  - Macrophages/immunology/*physiology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
MH  - Neuroglia/*cytology
MH  - Neurons/*physiology
MH  - *Phagocytosis
MH  - Retina/*cytology
PMC - PMC2112503
EDAT- 1983/07/01 00:00
MHDA- 1983/07/01 00:01
PMCR- 1984/01/01
CRDT- 1983/07/01 00:00
PHST- 1983/07/01 00:00 [pubmed]
PHST- 1983/07/01 00:01 [medline]
PHST- 1983/07/01 00:00 [entrez]
PHST- 1984/01/01 00:00 [pmc-release]
AID - 83238649 [pii]
AID - 10.1083/jcb.97.1.253 [doi]
PST - ppublish
SO  - J Cell Biol. 1983 Jul;97(1):253-7. doi: 10.1083/jcb.97.1.253.