PMID- 6371196
OWN - NLM
STAT- MEDLINE
DCOM- 19840601
LR  - 20191101
IS  - 0270-6474 (Print)
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Linking)
VI  - 4
IP  - 4
DP  - 1984 Apr
TI  - Cell determination and differentiation of identified serotonin-immunoreactive 
      neurons in the grasshopper embryo.
PG  - 989-1000
AB  - We have begun to investigate the factors that underlie neurotransmitter 
      determination in the central nervous system of the grasshopper embryo. The most 
      prominent serotonin-immunoreactive neurons in the segmental ganglia are three 
      clonally related interneurons, cells S1, S2, and S3. S1 and S2 are sibling 
      neurons and are the first two born in the family of neurons that is produced by 
      neuroblast 7-3; cell S3 derives from one of the second-born pair in the same 
      family. S1 is serotonin-immunoreactive in all thoracic and abdominal segments, S2 
      in all but two segments (T3 and A1), and S3 in only the prothorax (T1). These 
      segment-specific differences are not due to differential cell death but rather 
      can be ascribed to biochemical differences between lineally homologous neurons. 
      Furthermore, these homologous neurons also display interesting segment-specific 
      differences in their morphology. Laser ablation of neuroblast 7-3 before it 
      begins its series of programmed cell divisions results in the absence of its 
      normal serotonin-immunoreactive neuronal progeny when screened at mature stages. 
      These experiments support the hypothesis that transmitter determination is at 
      least in part regulated by cell lineage in the grasshopper embryo and that some 
      clonally related neurons appear to share a common transmitter determination by 
      virtue of their common lineage. The results further suggest that cell lineage 
      regulation of transmitter determination may vary according to segment or may be 
      modified by as yet unidentified segment-specific factors.
FAU - Taghert, P H
AU  - Taghert PH
FAU - Goodman, C S
AU  - Goodman CS
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 333DO1RDJY (Serotonin)
SB  - IM
MH  - Animals
MH  - Cell Differentiation
MH  - Central Nervous System/cytology/embryology/immunology
MH  - Grasshoppers/*embryology
MH  - Histocytochemistry
MH  - Immunologic Techniques
MH  - Neurons/cytology/*immunology/ultrastructure
MH  - Serotonin/*immunology
PMC - PMC6564790
EDAT- 1984/04/01 00:00
MHDA- 1984/04/01 00:01
PMCR- 1984/10/01
CRDT- 1984/04/01 00:00
PHST- 1984/04/01 00:00 [pubmed]
PHST- 1984/04/01 00:01 [medline]
PHST- 1984/04/01 00:00 [entrez]
PHST- 1984/10/01 00:00 [pmc-release]
AID - 10.1523/JNEUROSCI.04-04-00989.1984 [doi]
PST - ppublish
SO  - J Neurosci. 1984 Apr;4(4):989-1000. doi: 10.1523/JNEUROSCI.04-04-00989.1984.