PMID- 6433204
OWN - NLM
STAT- MEDLINE
DCOM- 19840926
LR  - 20220317
IS  - 0028-0836 (Print)
IS  - 0028-0836 (Linking)
VI  - 310
IP  - 5979
DP  - 1984 Aug 23-29
TI  - Inducible expression of H-2 and Ia antigens on brain cells.
PG  - 688-91
AB  - Cells in the brain express unusually low levels of antigens encoded by the major 
      histocompatibility complex (MHC). This is somewhat surprising as class I (H-2) 
      and class II (Ia) MHC antigens have critical roles in immune responses. The 
      activation of T lymphocytes is associated with the enhanced expression of these 
      antigens and this effect is mediated by a specific T-cell lymphokine, 
      gamma-interferon (IFN-gamma). Here we show that IFN-gamma induces a dramatic 
      increase in the expression of H-2 antigens on the cells of the brain. After 
      exposure to IFN-gamma in vitro, all surviving cells, including most astrocytes, 
      oligodendrocytes, microglia and at least some neurones, express H-2 antigens. 
      Direct injection of IFN-gamma into the brains of mice indicated that H-2 antigens 
      were also induced in vivo. Furthermore, IFN-gamma induced Ia antigens on a 
      subpopulation of astrocytes. The induction of H-2 antigens by IFN-gamma may 
      render brain cells competent to initiate and participate in immune reactions and 
      may therefore contribute to both immunoprotective and immunopathological 
      responses in the brain.
FAU - Wong, G H
AU  - Wong GH
FAU - Bartlett, P F
AU  - Bartlett PF
FAU - Clark-Lewis, I
AU  - Clark-Lewis I
FAU - Battye, F
AU  - Battye F
FAU - Schrader, J W
AU  - Schrader JW
LA  - eng
GR  - AI03958/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (H-2 Antigens)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Animals
MH  - Antibodies, Monoclonal
MH  - Astrocytes/drug effects/immunology
MH  - Brain/*immunology
MH  - Fluorescent Antibody Technique
MH  - *Genes, MHC Class II
MH  - H-2 Antigens/analysis/*genetics
MH  - Histocompatibility Antigens Class II/analysis
MH  - In Vitro Techniques
MH  - Interferon-gamma/pharmacology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Neurons/drug effects/immunology
MH  - Oligodendroglia/drug effects/immunology
EDAT- 1984/08/23 00:00
MHDA- 1984/08/23 00:01
CRDT- 1984/08/23 00:00
PHST- 1984/08/23 00:00 [pubmed]
PHST- 1984/08/23 00:01 [medline]
PHST- 1984/08/23 00:00 [entrez]
AID - 10.1038/310688a0 [doi]
PST - ppublish
SO  - Nature. 1984 Aug 23-29;310(5979):688-91. doi: 10.1038/310688a0.