PMID- 6438075
OWN - NLM
STAT- MEDLINE
DCOM- 19850114
LR  - 20190511
IS  - 0021-924X (Print)
IS  - 0021-924X (Linking)
VI  - 96
IP  - 3
DP  - 1984 Sep
TI  - Pathogenesis of serratial infection: activation of the Hageman 
      factor-prekallikrein cascade by serratial protease.
PG  - 739-49
AB  - A serratial protease with an apparent molecular weight of 56,000 (56K protease), 
      which had been purified from the culture supernatant of a strain of Serratia 
      marcescens isolated from a corneal lesion of a human eye [Matsumoto, K. et al. 
      (1984) J. Bacteriol. 157, 225-232], greatly enhanced vascular permeability when 
      injected into guinea pig skin. The 56K protease, which requires zinc ion for 
      activity, was found to possess plasma kallikrein-like properties in vitro as 
      judged by (i) preferential amidolysis of 
      carbobenzoxy-Phe-Arg-4-methylcoumaryl-7-amide and 
      Pro-Phe-Arg-4-methylcoumaryl-7-amide, which are known substrates for plasma 
      kallikrein; (ii) release of kinin from high-molecular-weight kininogen; and (iii) 
      prompt activation of Hageman factor followed by generation of kallikrein from 
      plasma prekallikrein. These results suggest that the 56K protease enhances 
      vascular permeability through activation of a Hageman factor-kallikrein-kinin 
      pathway in vivo, and this molecular process appears to be a rational mechanism of 
      enhancement of permeability and serratial pathogenesis.
FAU - Matsumoto, K
AU  - Matsumoto K
FAU - Yamamoto, T
AU  - Yamamoto T
FAU - Kamata, R
AU  - Kamata R
FAU - Maeda, H
AU  - Maeda H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Biochem
JT  - Journal of biochemistry
JID - 0376600
RN  - 9001-30-3 (Factor XII)
RN  - 9055-02-1 (Prekallikrein)
RN  - EC 3.4.- (Peptide Hydrolases)
RN  - EC 3.4.21.- (Kallikreins)
SB  - IM
MH  - Animals
MH  - Bacterial Infections/*physiopathology
MH  - Blood Coagulation
MH  - Corneal Diseases/*microbiology/physiopathology
MH  - Enzyme Activation
MH  - Factor XII/*metabolism
MH  - Female
MH  - Guinea Pigs
MH  - Humans
MH  - Immunodiffusion
MH  - Kallikreins/*metabolism
MH  - Kinetics
MH  - Male
MH  - Molecular Weight
MH  - Peptide Hydrolases/isolation & purification/*metabolism
MH  - Prekallikrein/*metabolism
MH  - Serratia marcescens/*enzymology/pathogenicity
MH  - Substrate Specificity
EDAT- 1984/09/01 00:00
MHDA- 1984/09/01 00:01
CRDT- 1984/09/01 00:00
PHST- 1984/09/01 00:00 [pubmed]
PHST- 1984/09/01 00:01 [medline]
PHST- 1984/09/01 00:00 [entrez]
AID - 10.1093/oxfordjournals.jbchem.a134892 [doi]
PST - ppublish
SO  - J Biochem. 1984 Sep;96(3):739-49. doi: 10.1093/oxfordjournals.jbchem.a134892.