PMID- 726520
OWN - NLM
STAT- MEDLINE
DCOM- 19790223
LR  - 20240109
IS  - 0049-8254 (Print)
IS  - 0049-8254 (Linking)
VI  - 8
IP  - 12
DP  - 1978 Dec
TI  - The metabolism and excretion of curcumin 
      (1,7-bis-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) in the rat.
PG  - 761-8
AB  - Curcumin labelled with deuterium and tritium was prepared. Oral and 
      intraperitoneal doses of [3H]curcumin led to the faecal excretion of most of the 
      radioactivity. 2. Intravenous and intraperitoneal doses of [3H]curcumin were well 
      excreted in the bile of cannulated rats. 3. The major biliary metabolites were 
      glucuronides of tetrahydrocurcumin and hexahydrocurcumin. A minor biliary 
      metabolite was dihydroferulic acid together with traces of ferulic acid. 
      Metabolites were identified using chemical ionization mass spectrometry.
FAU - Holder, G M
AU  - Holder GM
FAU - Plummer, J L
AU  - Plummer JL
FAU - Ryan, A J
AU  - Ryan AJ
LA  - eng
PT  - Journal Article
PL  - England
TA  - Xenobiotica
JT  - Xenobiotica; the fate of foreign compounds in biological systems
JID - 1306665
RN  - 0 (Catechols)
RN  - IT942ZTH98 (Curcumin)
SB  - IM
MH  - Animals
MH  - Bile/metabolism
MH  - Biotransformation
MH  - Catechols/*metabolism
MH  - Chemical Phenomena
MH  - Chemistry
MH  - Curcumin/*metabolism/urine
MH  - Feces/analysis
MH  - Magnetic Resonance Spectroscopy
MH  - Male
MH  - Mass Spectrometry
MH  - Rats
EDAT- 1978/12/01 00:00
MHDA- 1978/12/01 00:01
CRDT- 1978/12/01 00:00
PHST- 1978/12/01 00:00 [pubmed]
PHST- 1978/12/01 00:01 [medline]
PHST- 1978/12/01 00:00 [entrez]
AID - 10.3109/00498257809069589 [doi]
PST - ppublish
SO  - Xenobiotica. 1978 Dec;8(12):761-8. doi: 10.3109/00498257809069589.