PMID- 7489361
OWN - NLM
STAT- MEDLINE
DCOM- 19960102
LR  - 20221207
IS  - 1078-8956 (Print)
IS  - 1078-8956 (Linking)
VI  - 1
IP  - 10
DP  - 1995 Oct
TI  - Discovery of betulinic acid as a selective inhibitor of human melanoma that 
      functions by induction of apoptosis.
PG  - 1046-51
AB  - As a result of bioassay-guided fractionation, betulinic acid, a pentacyclic 
      triterpene, was identified as a melanoma-specific cytotoxic agent. In follow-up 
      studies conducted with athymic mice carrying human melanomas, tumour growth was 
      completely inhibited without toxicity. As judged by a variety of cellular 
      responses, antitumour activity was mediated by the induction of apoptosis. 
      Betulinic acid is inexpensive and available in abundant supply from common 
      natural sources, notably the bark of white birch trees. The compound is currently 
      undergoing preclinical development for the treatment or prevention of malignant 
      melanoma.
FAU - Pisha, E
AU  - Pisha E
AD  - Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, 
      University of Illinois at Chicago 60612, USA.
FAU - Chai, H
AU  - Chai H
FAU - Lee, I S
AU  - Lee IS
FAU - Chagwedera, T E
AU  - Chagwedera TE
FAU - Farnsworth, N R
AU  - Farnsworth NR
FAU - Cordell, G A
AU  - Cordell GA
FAU - Beecher, C W
AU  - Beecher CW
FAU - Fong, H H
AU  - Fong HH
FAU - Kinghorn, A D
AU  - Kinghorn AD
FAU - Brown, D M
AU  - Brown DM
AU  - et al.
LA  - eng
GR  - U01 CA 52956/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Nat Med
JT  - Nature medicine
JID - 9502015
RN  - 0 (Antineoplastic Agents, Phytogenic)
RN  - 0 (Growth Inhibitors)
RN  - 0 (Guanidines)
RN  - 0 (Pentacyclic Triterpenes)
RN  - 0 (Triterpenes)
RN  - SCQ4EZQ113 (pimagedine)
RN  - V10TVZ52E4 (Putrescine)
RN  - 4G6A18707N (Betulinic Acid)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents, Phytogenic/*pharmacology
MH  - Apoptosis
MH  - *DNA Damage
MH  - Growth Inhibitors/*pharmacology
MH  - Guanidines/pharmacology
MH  - Humans
MH  - Liver Neoplasms/pathology
MH  - Melanoma/*pathology
MH  - Melanoma, Experimental/pathology
MH  - Mice
MH  - Mice, Nude
MH  - Pentacyclic Triterpenes
MH  - Putrescine/pharmacology
MH  - Skin Neoplasms/pathology
MH  - Triterpenes/*pharmacology
MH  - Tumor Cells, Cultured/drug effects
MH  - Betulinic Acid
EDAT- 1995/10/01 00:00
MHDA- 1995/10/01 00:01
CRDT- 1995/10/01 00:00
PHST- 1995/10/01 00:00 [pubmed]
PHST- 1995/10/01 00:01 [medline]
PHST- 1995/10/01 00:00 [entrez]
AID - 10.1038/nm1095-1046 [doi]
PST - ppublish
SO  - Nat Med. 1995 Oct;1(10):1046-51. doi: 10.1038/nm1095-1046.