PMID- 7557389
OWN - NLM
STAT- MEDLINE
DCOM- 19951120
LR  - 20190524
IS  - 0890-9369 (Print)
IS  - 0890-9369 (Linking)
VI  - 9
IP  - 19
DP  - 1995 Oct 1
TI  - Lethal of scute, a proneural gene, participates in the specification of muscle 
      progenitors during Drosophila embryogenesis.
PG  - 2373-83
AB  - The mechanisms that underlie the segregation of muscle founder cells in the 
      Drosophila embryo are undefined. We show that the proneural gene lethal of scute 
      (l'sc) is expressed in clusters of cells in the somatic mesoderm, from which 
      individual muscle progenitors are singled out by progressive restriction of l'sc 
      expression. Coexpression of l'sc and S59 (a putative muscle identity gene) in a 
      subset of muscle progenitors shows that muscle founders are produced by division 
      of muscle progenitors. In neurogenic mutant embryos the restriction of l'sc 
      expression fails and all cells in a cluster coexpress l'sc and S59. 
      Loss-of-function and overexpression phenotypes indicate a role for l'sc in the 
      segregation of muscle progenitors and the formation of the muscle pattern.
FAU - Carmena, A
AU  - Carmena A
AD  - Centro de Biologia Molecular Severo Ochoa (C.S.I.C.-U.A.M.), Universidad 
      Autonoma, Madrid, Spain.
FAU - Bate, M
AU  - Bate M
FAU - Jimenez, F
AU  - Jimenez F
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genes Dev
JT  - Genes & development
JID - 8711660
RN  - 0 (Basic Helix-Loop-Helix Transcription Factors)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (Proteins)
RN  - 0 (Transcription Factors)
RN  - 0 (l(1)sc protein, Drosophila)
RN  - 0 (slou protein, Drosophila)
SB  - IM
MH  - Animals
MH  - Basic Helix-Loop-Helix Transcription Factors
MH  - Cell Differentiation/genetics
MH  - Drosophila/embryology/*genetics
MH  - *Drosophila Proteins
MH  - Gene Expression Regulation, Developmental/genetics
MH  - *Genes, Insect
MH  - *Homeodomain Proteins
MH  - Mesoderm/cytology/metabolism
MH  - Microscopy, Confocal
MH  - Muscles/*cytology/metabolism
MH  - Mutation/genetics
MH  - Phenotype
MH  - Proteins/genetics
MH  - Stem Cells/*cytology/metabolism
MH  - Transcription Factors/*genetics
EDAT- 1995/10/01 00:00
MHDA- 1995/10/01 00:01
CRDT- 1995/10/01 00:00
PHST- 1995/10/01 00:00 [pubmed]
PHST- 1995/10/01 00:01 [medline]
PHST- 1995/10/01 00:00 [entrez]
AID - 10.1101/gad.9.19.2373 [doi]
PST - ppublish
SO  - Genes Dev. 1995 Oct 1;9(19):2373-83. doi: 10.1101/gad.9.19.2373.