PMID- 7618084
OWN - NLM
STAT- MEDLINE
DCOM- 19950822
LR  - 20210108
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 269
IP  - 5221
DP  - 1995 Jul 14
TI  - Targeted disruption of mouse EGF receptor: effect of genetic background on mutant 
      phenotype.
PG  - 230-4
AB  - Gene targeting was used to create a null allele at the epidermal growth factor 
      receptor locus (Egfr). The phenotype was dependent on genetic background. EGFR 
      deficiency on a CF-1 background resulted in peri-implantation death due to 
      degeneration of the inner cell mass. On a 129/Sv background, homozygous mutants 
      died at mid-gestation due to placental defects; on a CD-1 background, the mutants 
      lived for up to 3 weeks and showed abnormalities in skin, kidney, brain, liver, 
      and gastrointestinal tract. The multiple abnormalities associated with EGFR 
      deficiency indicate that the receptor is involved in a wide range of cellular 
      activities.
FAU - Threadgill, D W
AU  - Threadgill DW
AD  - Department of Genetics, Case Western Reserve University, Cleveland, OH 
      44106-4955, USA.
FAU - Dlugosz, A A
AU  - Dlugosz AA
FAU - Hansen, L A
AU  - Hansen LA
FAU - Tennenbaum, T
AU  - Tennenbaum T
FAU - Lichti, U
AU  - Lichti U
FAU - Yee, D
AU  - Yee D
FAU - LaMantia, C
AU  - LaMantia C
FAU - Mourton, T
AU  - Mourton T
FAU - Herrup, K
AU  - Herrup K
FAU - Harris, R C
AU  - Harris RC
AU  - et al.
LA  - eng
GR  - GM14630/GM/NIGMS NIH HHS/United States
GR  - HD07104/HD/NICHD NIH HHS/United States
GR  - HD26722/HD/NICHD NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - EC 2.7.10.1 (ErbB Receptors)
SB  - IM
GS  - Egfr
MH  - Abnormalities, Multiple/*genetics
MH  - Animals
MH  - Base Sequence
MH  - Brain/abnormalities/cytology
MH  - Cell Division
MH  - Digestive System/cytology
MH  - Digestive System Abnormalities
MH  - *Embryonic and Fetal Development
MH  - ErbB Receptors/deficiency/*genetics/*physiology
MH  - Female
MH  - *Gene Targeting
MH  - Hair/abnormalities
MH  - Homozygote
MH  - Kidney/cytology
MH  - Lung/cytology
MH  - Male
MH  - Mice
MH  - Molecular Sequence Data
MH  - Mutation
MH  - Phenotype
MH  - Skin/cytology
MH  - Skin Abnormalities
EDAT- 1995/07/14 00:00
MHDA- 1995/07/14 00:01
CRDT- 1995/07/14 00:00
PHST- 1995/07/14 00:00 [pubmed]
PHST- 1995/07/14 00:01 [medline]
PHST- 1995/07/14 00:00 [entrez]
AID - 10.1126/science.7618084 [doi]
PST - ppublish
SO  - Science. 1995 Jul 14;269(5221):230-4. doi: 10.1126/science.7618084.