PMID- 7682011
OWN - NLM
STAT- MEDLINE
DCOM- 19930430
LR  - 20220310
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 260
IP  - 5104
DP  - 1993 Apr 2
TI  - Skn-1a and Skn-1i: two functionally distinct Oct-2-related factors expressed in 
      epidermis.
PG  - 78-82
AB  - Two forms of a member of the POU domain family of transcriptional regulators, 
      highly related to Oct-2, are selectively expressed in terminally differentiating 
      epidermis and hair follicles. One form, referred to as Skn-1i, contains an 
      amino-terminal domain that inhibits DNA binding and can inhibit transactivation 
      by Oct-1. A second form, Skn-1a, contains an alternative amino terminus and 
      serves to activate cytokeratin 10 (K10) gene expression. The pattern of 
      expression of the Skn-1a/i gene products and the effect of the alternative 
      products on the expression of other genes suggest that these factors serve 
      regulatory functions with respect to epidermal development.
FAU - Andersen, B
AU  - Andersen B
AD  - Eukaryotic Regulatory Biology Program, Howard Hughes Medical Institute, 
      University of California School of Medicine, San Diego, La Jolla 92093.
FAU - Schonemann, M D
AU  - Schonemann MD
FAU - Flynn, S E
AU  - Flynn SE
FAU - Pearse, R V 2nd
AU  - Pearse RV 2nd
FAU - Singh, H
AU  - Singh H
FAU - Rosenfeld, M G
AU  - Rosenfeld MG
LA  - eng
SI  - GENBANK/L23862
SI  - GENBANK/L23863
GR  - DK39949/DK/NIDDK NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Basic-Leucine Zipper Transcription Factors)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Macromolecular Substances)
RN  - 0 (Octamer Transcription Factor-2)
RN  - 0 (Pou2f2 protein, mouse)
RN  - 0 (Pou2f2 protein, rat)
RN  - 0 (Repressor Proteins)
RN  - 0 (TEF protein, human)
RN  - 0 (Tef protein, mouse)
RN  - 0 (Transcription Factors)
RN  - 68238-35-7 (Keratins)
RN  - 9007-49-2 (DNA)
SB  - IM
EIN - Science. 1993 Dec 3;262(5139):1499. PMID: 8248794
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Basic-Leucine Zipper Transcription Factors
MH  - DNA/chemistry/genetics/metabolism
MH  - DNA-Binding Proteins/chemistry/*genetics
MH  - Epidermis/*metabolism
MH  - *Gene Expression/drug effects
MH  - Keratins/genetics
MH  - Leucine Zippers
MH  - Macromolecular Substances
MH  - Mice
MH  - Molecular Sequence Data
MH  - Nucleic Acid Hybridization
MH  - Octamer Transcription Factor-2
MH  - Polymerase Chain Reaction
MH  - *Repressor Proteins
MH  - Sequence Homology, Amino Acid
MH  - Transcription Factors/chemistry/*genetics/metabolism/pharmacology
EDAT- 1993/04/02 00:00
MHDA- 1993/04/02 00:01
CRDT- 1993/04/02 00:00
PHST- 1993/04/02 00:00 [pubmed]
PHST- 1993/04/02 00:01 [medline]
PHST- 1993/04/02 00:00 [entrez]
AID - 10.1126/science.7682011 [doi]
PST - ppublish
SO  - Science. 1993 Apr 2;260(5104):78-82. doi: 10.1126/science.7682011.