PMID- 7694057
OWN - NLM
STAT- MEDLINE
DCOM- 19931201
LR  - 20190821
IS  - 0306-9877 (Print)
IS  - 0306-9877 (Linking)
VI  - 41
IP  - 2
DP  - 1993 Aug
TI  - A disturbance of interferon synthesis with the hyperproduction of unusual kinds 
      of interferon can trigger autoimmune disease and play a pathogenetic role in 
      AIDS: the removal of these interferons can be therapeutic.
PG  - 177-85
AB  - Disturbances of interferon synthesis with the hyperproduction of unusual kinds of 
      interferons may be the initial step which triggers autoimmune disease through a 
      concatenation of pathological reactions including the disturbance of several 
      immunological and interferon cascades. This fundamental disturbance can result 
      either from a genetic predisposition or from the influence of certain viruses (or 
      viral particles) or both factors together. The administration of interferons to 
      individuals with an underlying or latent autoimmune condition can exacerbate or 
      trigger the disease. AIDS has many features similar to autoimmune disease, 
      including the hyperproduction of aberrant interferon, a type with little or no 
      anti-HIV activity, protectively induced by HIV to allow its continued replication 
      and survival. In other words, while most viruses induce normal IFN which protects 
      the cells against viral infection, HIV induces an abnormal, defective kind of IFN 
      which insures viral survival. The neutralization of hyperproduced interferons by 
      polyclonal or monoclonal antibody produced in mouse, or preferably, human 
      hybridoma, removal via extracorporeal means, or the use of antagonists which 
      diminish the production or biological activity of these interferons can be a 
      therapeutic approach to the management of these chronic diseases. In addition, 
      the extracorporeal removal of different kinds of interferons, autoantibodies, 
      autoantigens and other substances from the organism in certain pathological 
      conditions may be an effective and safe method of treatment for autoimmune 
      diseases and AIDS.
FAU - Skurkovich, S
AU  - Skurkovich S
AD  - Advanced Biotherapy Concepts Labs, Rockville, MD.
FAU - Skurkovich, B
AU  - Skurkovich B
FAU - Bellanti, J A
AU  - Bellanti JA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Hypotheses
JT  - Medical hypotheses
JID - 7505668
RN  - 0 (HLA-D Antigens)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 9008-11-1 (Interferons)
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/*immunology/*physiopathology/therapy
MH  - Animals
MH  - Autoimmune Diseases/*physiopathology/therapy
MH  - HLA-D Antigens/biosynthesis
MH  - Histocompatibility Antigens Class II/biosynthesis
MH  - Humans
MH  - Interferons/*biosynthesis
MH  - *Models, Biological
EDAT- 1993/08/01 00:00
MHDA- 1993/08/01 00:01
CRDT- 1993/08/01 00:00
PHST- 1993/08/01 00:00 [pubmed]
PHST- 1993/08/01 00:01 [medline]
PHST- 1993/08/01 00:00 [entrez]
AID - 0306-9877(93)90066-Y [pii]
AID - 10.1016/0306-9877(93)90066-y [doi]
PST - ppublish
SO  - Med Hypotheses. 1993 Aug;41(2):177-85. doi: 10.1016/0306-9877(93)90066-y.