PMID- 7713785
OWN - NLM
STAT- MEDLINE
DCOM- 19950515
LR  - 20220331
IS  - 0360-3016 (Print)
IS  - 0360-3016 (Linking)
VI  - 31
IP  - 5
DP  - 1995 Mar 30
TI  - Hepatic toxicity resulting from cancer treatment.
PG  - 1237-48
AB  - Radiation-induced liver disease (RILD), often called radiation hepatitis, is a 
      syndrome characterized by the development of anicteric ascites approximately 2 
      weeks to 4 months after hepatic irradiation. There has been a renewed interest in 
      hepatic irradiation because of two significant advances in cancer treatment: 
      three dimensional radiation therapy treatment planning and bone marrow 
      transplantation using total body irradiation. RILD resulting from liver radiation 
      can usually be distinguished clinically from that resulting from the preparative 
      regime associated with bone marrow transplantation. However, both syndromes 
      demonstrate the same pathological lesion: veno-occlusive disease. Recent evidence 
      suggests that elevated transforming growth factor beta levels may play a role in 
      the development of veno-occlusive disease. Three dimensional treatment planning 
      offers the potential to determine the radiation dose and volume dependence of 
      RILD, permitting the safe delivery of high doses of radiation to parts of the 
      liver. The chief therapy for RILD is diuretics, although some advocate steroids 
      for severe cases. The characteristics of RILD permit the development of a grading 
      system modeled after the NCI Acute Common Toxicity Criteria, which incorporates 
      standard criteria of hepatic dysfunction.
FAU - Lawrence, T S
AU  - Lawrence TS
AD  - Department of Radiation Oncology, University of Michigan Medical Center, Ann 
      Arbor 48109, USA.
FAU - Robertson, J M
AU  - Robertson JM
FAU - Anscher, M S
AU  - Anscher MS
FAU - Jirtle, R L
AU  - Jirtle RL
FAU - Ensminger, W D
AU  - Ensminger WD
FAU - Fajardo, L F
AU  - Fajardo LF
LA  - eng
GR  - CA25951/CA/NCI NIH HHS/United States
GR  - CA40172/CA/NCI NIH HHS/United States
GR  - M01R00042/PHS HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Int J Radiat Oncol Biol Phys
JT  - International journal of radiation oncology, biology, physics
JID - 7603616
SB  - IM
MH  - Dose-Response Relationship, Radiation
MH  - Hepatic Veno-Occlusive Disease/etiology/pathology
MH  - Hepatitis/etiology/physiopathology
MH  - Humans
MH  - Liver/anatomy & histology/physiology/*radiation effects
MH  - Liver Diseases/complications/*etiology/physiopathology
MH  - Radiation Injuries/*complications/physiopathology
MH  - Radiation Tolerance
MH  - Radiotherapy/*adverse effects
MH  - Severity of Illness Index
MH  - Time Factors
RF  - 64
EDAT- 1995/03/30 00:00
MHDA- 1995/03/30 00:01
CRDT- 1995/03/30 00:00
PHST- 1995/03/30 00:00 [pubmed]
PHST- 1995/03/30 00:01 [medline]
PHST- 1995/03/30 00:00 [entrez]
AID - 0360-3016(94)00418-K [pii]
AID - 10.1016/0360-3016(94)00418-K [doi]
PST - ppublish
SO  - Int J Radiat Oncol Biol Phys. 1995 Mar 30;31(5):1237-48. doi: 
      10.1016/0360-3016(94)00418-K.