PMID- 7773690
OWN - NLM
STAT- MEDLINE
DCOM- 19950711
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 674
IP  - 1
DP  - 1995 Mar 13
TI  - Passage of peptides through the blood-brain barrier with colloidal polymer 
      particles (nanoparticles).
PG  - 171-4
AB  - Transport of the hexapeptide dalargin across the blood-brain barrier was 
      accomplished using a nanoparticle formulation. The formulation consisted of 
      dalargin bound to poly(butyl cyanoacrylate) nanoparticles by sorption, coated 
      with polysorbate 80. Intravenous injection of this formulation to mice resulted 
      in an analgesic effect. All controls, including a simple mixture of the three 
      components (drugs, nanoparticles, and surfactant) mixed directly before i.v. 
      injection, exhibited no effect. Analgesia was also prevented by pretreatment with 
      naloxone. Fluorescent and electron microscopic studies indicated that the passage 
      of the particle-bound drug occurred by phagocytic uptake of the polysorbate 
      80-coated nanoparticles by the brain blood vessel endothelial cells.
FAU - Kreuter, J
AU  - Kreuter J
AD  - Institut fur Pharmazeutische Technologie, Johann Wolfgang Goethe-Universitat, 
      Frankfurt am Main, Germany.
FAU - Alyautdin, R N
AU  - Alyautdin RN
FAU - Kharkevich, D A
AU  - Kharkevich DA
FAU - Ivanov, A A
AU  - Ivanov AA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Colloids)
RN  - 0 (Peptides)
RN  - 0 (Polymers)
RN  - 0 (Polysorbates)
RN  - 63631-40-3 (Enkephalin, Leucine-2-Alanine)
RN  - V13505565P (enkephalin-Leu, Ala(2)-Arg(6)-)
SB  - IM
MH  - Animals
MH  - *Blood-Brain Barrier
MH  - Colloids/*pharmacokinetics
MH  - Enkephalin, Leucine-2-Alanine/analogs & derivatives/pharmacokinetics
MH  - Injections, Intravenous
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Microscopy, Electron
MH  - Microscopy, Fluorescence
MH  - Particle Size
MH  - Peptides/*pharmacokinetics
MH  - Polymers/*pharmacokinetics
MH  - Polysorbates
EDAT- 1995/03/13 00:00
MHDA- 1995/03/13 00:01
CRDT- 1995/03/13 00:00
PHST- 1995/03/13 00:00 [pubmed]
PHST- 1995/03/13 00:01 [medline]
PHST- 1995/03/13 00:00 [entrez]
AID - 0006-8993(95)00023-J [pii]
AID - 10.1016/0006-8993(95)00023-j [doi]
PST - ppublish
SO  - Brain Res. 1995 Mar 13;674(1):171-4. doi: 10.1016/0006-8993(95)00023-j.