PMID- 7782338
OWN - NLM
STAT- MEDLINE
DCOM- 19950717
LR  - 20211203
IS  - 0021-9258 (Print)
IS  - 0021-9258 (Linking)
VI  - 270
IP  - 24
DP  - 1995 Jun 16
TI  - Characterization of the mammalian YAP (Yes-associated protein) gene and its role 
      in defining a novel protein module, the WW domain.
PG  - 14733-41
AB  - We report cDNA cloning and characterization of the human and mouse orthologs of 
      the chicken YAP (Yes-associated protein) gene which encodes a novel protein that 
      binds to the SH3 (Src homology 3) domain of the Yes proto-oncogene product. 
      Sequence comparison between mouse, human, and chicken YAP proteins showed an 
      inserted sequence in the mouse YAP that represented an imperfect repeat of an 
      upstream sequence. Further analysis of this sequence revealed a putative protein 
      module that is found in various structural, regulatory, and signaling molecules 
      in yeast, nematode, and mammals including human dystrophin. Because one of the 
      prominent features of this sequence motif is two tryptophans (W), we named it the 
      WW domain (Bork, P., and Sudol, M. (1994) Trends Biochem. Sci. 19, 531-533). 
      Since its delineation, more proteins have been shown to contain this domain, and 
      we report here on the widespread distribution of the WW module and present a 
      discussion of its possible function. We have also shown that the human YAP gene 
      is well conserved among higher eukaryotes, but it may not be conserved in yeast. 
      Its expression at the RNA level in adult human tissues is nearly ubiquitous, 
      being relatively high in placenta, prostate, ovary, and testis, but is not 
      detectable in peripheral blood leukocytes. Using fluorescence in situ 
      hybridization on human metaphase chromosomes and by analyzing rodent-human 
      hybrids by Southern blot hybridization and polymerase chain reaction 
      amplification, we mapped the human YAP gene to chromosome band 11q13, a region to 
      which the multiple endocrine neoplasia type 1 gene has been mapped.
FAU - Sudol, M
AU  - Sudol M
AD  - Laboratory of Molecular Oncology, Rockefeller University, New York, New York 
      10021, USA.
FAU - Bork, P
AU  - Bork P
FAU - Einbond, A
AU  - Einbond A
FAU - Kastury, K
AU  - Kastury K
FAU - Druck, T
AU  - Druck T
FAU - Negrini, M
AU  - Negrini M
FAU - Huebner, K
AU  - Huebner K
FAU - Lehman, D
AU  - Lehman D
LA  - eng
SI  - GENBANK/X80507
SI  - GENBANK/X80508
GR  - CA01605/CA/NCI NIH HHS/United States
GR  - CA45757/CA/NCI NIH HHS/United States
GR  - CA51083/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Biol Chem
JT  - The Journal of biological chemistry
JID - 2985121R
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Carrier Proteins)
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (DNA, Complementary)
RN  - 0 (MAS1 protein, human)
RN  - 0 (Phosphoproteins)
RN  - 0 (Proto-Oncogene Mas)
RN  - 0 (RNA, Messenger)
RN  - 0 (Transcription Factors)
RN  - 0 (YAP-Signaling Proteins)
RN  - 0 (YAP1 protein, human)
RN  - 0 (Yap1 protein, mouse)
SB  - IM
GS  - YAP
MH  - *Adaptor Proteins, Signal Transducing
MH  - Adult
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Biological Evolution
MH  - Carrier Proteins/chemistry/*genetics
MH  - Cell Cycle Proteins
MH  - Chickens
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 11
MH  - Chromosomes, Human, Pair 6
MH  - Cloning, Molecular
MH  - DNA, Complementary
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Molecular Sequence Data
MH  - Phosphoproteins/chemistry/*genetics
MH  - Proto-Oncogene Mas
MH  - RNA, Messenger/genetics/metabolism
MH  - Sequence Homology, Amino Acid
MH  - Transcription Factors
MH  - YAP-Signaling Proteins
EDAT- 1995/06/16 00:00
MHDA- 1995/06/16 00:01
CRDT- 1995/06/16 00:00
PHST- 1995/06/16 00:00 [pubmed]
PHST- 1995/06/16 00:01 [medline]
PHST- 1995/06/16 00:00 [entrez]
AID - S0021-9258(18)92117-4 [pii]
AID - 10.1074/jbc.270.24.14733 [doi]
PST - ppublish
SO  - J Biol Chem. 1995 Jun 16;270(24):14733-41. doi: 10.1074/jbc.270.24.14733.