PMID- 7790697
OWN - NLM
STAT- MEDLINE
DCOM- 19950721
LR  - 20230131
IS  - 0731-5724 (Print)
IS  - 0731-5724 (Linking)
VI  - 14
IP  - 2
DP  - 1995 Apr
TI  - Effects of a ketogenic diet on tumor metabolism and nutritional status in 
      pediatric oncology patients: two case reports.
PG  - 202-8
AB  - OBJECTIVE: Establish dietary-induced ketosis in pediatric oncology patients to 
      determine if a ketogenic state would decrease glucose availability to certain 
      tumors, thereby potentially impairing tumor metabolism without adversely 
      affecting the patient's overall nutritional status. DESIGN: Case report. SETTING: 
      University Hospitals of Cleveland. SUBJECTS: Two female pediatric patients with 
      advanced stage malignant Astrocytoma tumors. INTERVENTIONS: Patients were 
      followed as outpatients for 8 weeks. Ketosis was maintained by consuming a 60% 
      medium chain triglyceride oil-based diet. MAIN OUTCOME MEASURES: Tumor glucose 
      metabolism was assessed by Positron Emission Tomography (PET), comparing 
      [Fluorine-18] 2-deoxy-2-fluoro-D-glucose (FDG) uptake at the tumor site before 
      and following the trial period. RESULTS: Within 7 days of initiating the 
      ketogenic diet, blood glucose levels declined to low-normal levels and blood 
      ketones were elevated twenty to thirty fold. Results of PET scans indicated a 
      21.8% average decrease in glucose uptake at the tumor site in both subjects. One 
      patient exhibited significant clinical improvements in mood and new skill 
      development during the study. She continued the ketogenic diet for an additional 
      twelve months, remaining free of disease progression. CONCLUSION: While this diet 
      does not replace conventional antineoplastic treatments, these preliminary 
      results suggest a potential for clinical application which merits further 
      research.
FAU - Nebeling, L C
AU  - Nebeling LC
AD  - Nutrition Department, Case Western Reserve University, School of Medicine, 
      Cleveland, Ohio, USA.
FAU - Miraldi, F
AU  - Miraldi F
FAU - Shurin, S B
AU  - Shurin SB
FAU - Lerner, E
AU  - Lerner E
LA  - eng
GR  - M01 RR00080-29/RR/NCRR NIH HHS/United States
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Am Coll Nutr
JT  - Journal of the American College of Nutrition
JID - 8215879
RN  - 0 (Dietary Fats, Unsaturated)
RN  - 0 (Triglycerides)
SB  - IM
MH  - Astrocytoma/*diet therapy/metabolism
MH  - Cerebellar Neoplasms/*diet therapy/metabolism
MH  - Child
MH  - Child, Preschool
MH  - *Diet
MH  - Dietary Fats, Unsaturated/administration & dosage
MH  - Female
MH  - Humans
MH  - Ketosis/etiology/*metabolism
MH  - *Nutritional Status
MH  - Spinal Cord Neoplasms/*diet therapy/metabolism
MH  - Triglycerides/administration & dosage
EDAT- 1995/04/01 00:00
MHDA- 1995/04/01 00:01
CRDT- 1995/04/01 00:00
PHST- 1995/04/01 00:00 [pubmed]
PHST- 1995/04/01 00:01 [medline]
PHST- 1995/04/01 00:00 [entrez]
AID - 10.1080/07315724.1995.10718495 [doi]
PST - ppublish
SO  - J Am Coll Nutr. 1995 Apr;14(2):202-8. doi: 10.1080/07315724.1995.10718495.