PMID- 7815531
OWN - NLM
STAT- MEDLINE
DCOM- 19950209
LR  - 20200724
IS  - 0022-538X (Print)
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Linking)
VI  - 69
IP  - 2
DP  - 1995 Feb
TI  - Mouse hepatitis virus-specific cytotoxic T lymphocytes protect from lethal 
      infection without eliminating virus from the central nervous system.
PG  - 684-94
AB  - Acute infection of the central nervous system by the neurotropic JHM strain of 
      mouse hepatitis virus (JHMV) induces nucleocapsid protein specific cytotoxic T 
      lymphocytes (CTL) not found in the periphery (S. Stohlman, S. Kyuwa, J. Polo, D. 
      Brady, M. Lai, and C. Bergmann, J. Virol. 67:7050-7059, 1993). Peripheral 
      induction of CTL specific for the nucleocapsid protein of JHMV by vaccination 
      with recombinant vaccinia viruses was unable to provide significant protection to 
      a subsequent lethal virus challenge. By contrast, the transfer of 
      nucleoprotein-specific CTL protected mice from a subsequent lethal challenge by 
      reducing virus replication within the central nervous system, demonstrating the 
      importance of the CTL response to this epitope in JHMV infection. Transfer of 
      these CTL directly into the central nervous system was at least 10-fold more 
      effective than peripheral transfer. Histological analysis indicated that the CTL 
      reduced virus replication in ependymal cells, astrocytes, and microglia. Although 
      the CTL were relatively ineffective at reducing virus replication in 
      oligodendroglia, survivors showed minimal evidence of virus persistence within 
      the central nervous system and no evidence of chronic ongoing demyelination.
FAU - Stohlman, S A
AU  - Stohlman SA
AD  - Department of Neurology, USC School of Medicine, Los Angeles 90033.
FAU - Bergmann, C C
AU  - Bergmann CC
FAU - van der Veen, R C
AU  - van der Veen RC
FAU - Hinton, D R
AU  - Hinton DR
LA  - eng
GR  - NS18146/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Viral Core Proteins)
SB  - IM
MH  - Animals
MH  - Brain/*virology
MH  - Capsid/immunology
MH  - Coronavirus Infections/pathology/*prevention & control
MH  - Histocompatibility Antigens Class I/immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
MH  - Murine hepatitis virus/*immunology
MH  - T-Lymphocytes, Cytotoxic/*immunology
MH  - Vaccination
MH  - Viral Core Proteins/immunology
PMC - PMC188629
EDAT- 1995/02/01 00:00
MHDA- 1995/02/01 00:01
PMCR- 1995/02/01
CRDT- 1995/02/01 00:00
PHST- 1995/02/01 00:00 [pubmed]
PHST- 1995/02/01 00:01 [medline]
PHST- 1995/02/01 00:00 [entrez]
PHST- 1995/02/01 00:00 [pmc-release]
AID - 10.1128/JVI.69.2.684-694.1995 [doi]
PST - ppublish
SO  - J Virol. 1995 Feb;69(2):684-94. doi: 10.1128/JVI.69.2.684-694.1995.