PMID- 7824938
OWN - NLM
STAT- MEDLINE
DCOM- 19950213
LR  - 20220316
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 267
IP  - 5196
DP  - 1995 Jan 20
TI  - Transcription factor ATF2 regulation by the JNK signal transduction pathway.
PG  - 389-93
AB  - Treatment of cells with pro-inflammatory cytokines or ultraviolet radiation 
      causes activation of the c-Jun NH2-terminal protein kinase (JNK). Activating 
      transcription factor-2 (ATF2) was found to be a target of the JNK signal 
      transduction pathway. ATF2 was phosphorylated by JNK on two closely spaced 
      threonine residues within the NH2-terminal activation domain. The replacement of 
      these phosphorylation sites with alanine inhibited the transcriptional activity 
      of ATF2. These mutations also inhibited ATF2-stimulated gene expression mediated 
      by the retinoblastoma (Rb) tumor suppressor and the adenovirus early region 1A 
      (E1A) oncoprotein. Furthermore, expression of dominant-negative JNK inhibited 
      ATF2 transcriptional activity. Together, these data demonstrate a role for the 
      JNK signal transduction pathway in transcriptional responses mediated by ATF2.
FAU - Gupta, S
AU  - Gupta S
AD  - Department of Biochemistry and Molecular Biology, University of Massachusetts 
      Medical School, Worcester 01605.
FAU - Campbell, D
AU  - Campbell D
FAU - Derijard, B
AU  - Derijard B
FAU - Davis, R J
AU  - Davis RJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Activating Transcription Factor 2)
RN  - 0 (Adenovirus E1A Proteins)
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - 0 (Interleukin-1)
RN  - 0 (Retinoblastoma Protein)
RN  - 0 (Transcription Factors)
RN  - 9007-49-2 (DNA)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinases)
RN  - EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
SB  - IM
MH  - Activating Transcription Factor 2
MH  - Adenovirus E1A Proteins/physiology
MH  - Animals
MH  - Base Sequence
MH  - CHO Cells
MH  - Calcium-Calmodulin-Dependent Protein Kinases/*metabolism
MH  - Cricetinae
MH  - Cyclic AMP Response Element-Binding Protein/chemistry/genetics/*metabolism
MH  - DNA/metabolism
MH  - Interleukin-1/pharmacology
MH  - JNK Mitogen-Activated Protein Kinases
MH  - *Leucine Zippers
MH  - *Mitogen-Activated Protein Kinases
MH  - Molecular Sequence Data
MH  - Mutagenesis, Site-Directed
MH  - Phosphorylation
MH  - Point Mutation
MH  - Promoter Regions, Genetic
MH  - Retinoblastoma Protein/physiology
MH  - *Signal Transduction
MH  - *Transcription Factors
MH  - *Transcription, Genetic
MH  - Ultraviolet Rays
EDAT- 1995/01/20 00:00
MHDA- 1995/01/20 00:01
CRDT- 1995/01/20 00:00
PHST- 1995/01/20 00:00 [pubmed]
PHST- 1995/01/20 00:01 [medline]
PHST- 1995/01/20 00:00 [entrez]
AID - 10.1126/science.7824938 [doi]
PST - ppublish
SO  - Science. 1995 Jan 20;267(5196):389-93. doi: 10.1126/science.7824938.