PMID- 7845373
OWN - NLM
STAT- MEDLINE
DCOM- 19950306
LR  - 20190818
IS  - 0300-8177 (Print)
IS  - 0300-8177 (Linking)
VI  - 137
IP  - 1
DP  - 1994 Aug 17
TI  - Studies on the inhibitory effects of curcumin and eugenol on the formation of 
      reactive oxygen species and the oxidation of ferrous iron.
PG  - 1-8
AB  - The spice principles curcumin (from turmeric) and eugenol (from cloves) are good 
      inhibitors of lipid peroxidation. Lipid peroxidation is known to be initiated by 
      reactive oxygen species. The effect of curcumin and eugenol on the generation of 
      reactive oxygen species in model systems were investigated. Both curcumin and 
      eugenol inhibited superoxide anion generation in xanthine-xanthine oxidase system 
      to an extent of 40% and 50% at concentrations of 75 microM and 250 microM 
      respectively. Curcumin and eugenol also inhibited the generation of hydroxyl 
      radicals (.OH) to an extent of 76% and 70% as measured by deoxyribose 
      degradation. The .OH-radical formation measured by the hydroxylation of 
      salicylate to 2,3-dihydroxy benzoate was inhibited to an extent of 66% and 46%, 
      respectively, by curcumin and eugenol at 50 microM and 250 microM. These spice 
      principles also prevented the oxidation of Fe2+ in Fentons reaction which 
      generates .OH radicals.
FAU - Reddy, A C
AU  - Reddy AC
AD  - Department of Biochemistry and Nutrition, Central Food Technological Research 
      Institute, Mysore, India.
FAU - Lokesh, B R
AU  - Lokesh BR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Mol Cell Biochem
JT  - Molecular and cellular biochemistry
JID - 0364456
RN  - 0 (Reactive Oxygen Species)
RN  - 0 (Xanthines)
RN  - 11062-77-4 (Superoxides)
RN  - 1AVZ07U9S7 (Xanthine)
RN  - 3352-57-6 (Hydroxyl Radical)
RN  - 3T8H1794QW (Eugenol)
RN  - 533-67-5 (Deoxyribose)
RN  - E1UOL152H7 (Iron)
RN  - EC 1.17.3.2 (Xanthine Oxidase)
RN  - IT942ZTH98 (Curcumin)
SB  - IM
MH  - Curcumin/*pharmacology
MH  - Deoxyribose/metabolism
MH  - Eugenol/*pharmacology
MH  - Hydroxyl Radical/metabolism
MH  - Iron/*metabolism
MH  - Lipid Peroxidation/*drug effects
MH  - Oxidation-Reduction
MH  - Reactive Oxygen Species/*metabolism
MH  - Superoxides/metabolism
MH  - Xanthine
MH  - Xanthine Oxidase/metabolism
MH  - Xanthines/metabolism
EDAT- 1994/08/17 00:00
MHDA- 1994/08/17 00:01
CRDT- 1994/08/17 00:00
PHST- 1994/08/17 00:00 [pubmed]
PHST- 1994/08/17 00:01 [medline]
PHST- 1994/08/17 00:00 [entrez]
AID - 10.1007/BF00926033 [doi]
PST - ppublish
SO  - Mol Cell Biochem. 1994 Aug 17;137(1):1-8. doi: 10.1007/BF00926033.