PMID- 7847867
OWN - NLM
STAT- MEDLINE
DCOM- 19950307
LR  - 20221207
IS  - 0364-5134 (Print)
IS  - 0364-5134 (Linking)
VI  - 37
IP  - 2
DP  - 1995 Feb
TI  - Apolipoprotein E and Alzheimer's disease: ethnic variation in genotypic risks.
PG  - 254-9
AB  - The presence of the apolipoprotein epsilon 4 (apo epsilon 4) allele significantly 
      increases the risk of Alzheimer's disease. Whether this is due to biological 
      effects of the apo epsilon 4 protein or reflects linkage disequilibrium with an 
      as yet unidentified Alzheimer's disease susceptibility gene is of critical 
      importance. In a community study in northern Manhattan we found a fivefold 
      increase in the risk of Alzheimer's disease among African-Americans, Hispanics, 
      and whites homozygous for apo epsilon 4. Overall, the risk between Alzheimer's 
      disease and apo epsilon 4 heterozygosity was also increased by twofold, but the 
      association was somewhat weaker for African-Americans than for Hispanics and 
      whites. In contrast, the apo epsilon 2/epsilon 3 genotype was associated with an 
      eightfold increased risk of Alzheimer's disease in African-Americans but it was 
      associated with reduced risk in whites. Variability in the strength and type of 
      association between Alzheimer's disease and the apo E polymorphisms in the three 
      ethnic groups could not be fully explained by age differences. The allelic 
      frequency of apo epsilon *4 was significantly higher in patients than control 
      subjects in all ethnic groups at age 70 or younger, reflecting the higher 
      proportion of apo epsilon 4 homozygotes, but this difference diminished with 
      increasing age. The allelic frequency of apo epsilon *2 for African-Americans and 
      Hispanics, but not whites, was significantly higher in patients than control 
      subjects, but only after age 70.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Maestre, G
AU  - Maestre G
AD  - Center for Alzheimer's Disease Research, New York, NY.
FAU - Ottman, R
AU  - Ottman R
FAU - Stern, Y
AU  - Stern Y
FAU - Gurland, B
AU  - Gurland B
FAU - Chun, M
AU  - Chun M
FAU - Tang, M X
AU  - Tang MX
FAU - Shelanski, M
AU  - Shelanski M
FAU - Tycko, B
AU  - Tycko B
FAU - Mayeux, R
AU  - Mayeux R
LA  - eng
GR  - AG07232/AG/NIA NIH HHS/United States
GR  - AG08702/AG/NIA NIH HHS/United States
GR  - AG10963/AG/NIA NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Ann Neurol
JT  - Annals of neurology
JID - 7707449
RN  - 0 (Apolipoproteins E)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Alzheimer Disease/*ethnology/genetics
MH  - Apolipoproteins E/*genetics
MH  - Black People/genetics
MH  - Case-Control Studies
MH  - Female
MH  - Genotype
MH  - Hispanic or Latino/genetics
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - White People/genetics
EDAT- 1995/02/01 00:00
MHDA- 1995/02/01 00:01
CRDT- 1995/02/01 00:00
PHST- 1995/02/01 00:00 [pubmed]
PHST- 1995/02/01 00:01 [medline]
PHST- 1995/02/01 00:00 [entrez]
AID - 10.1002/ana.410370217 [doi]
PST - ppublish
SO  - Ann Neurol. 1995 Feb;37(2):254-9. doi: 10.1002/ana.410370217.