PMID- 7848517
OWN - NLM
STAT- MEDLINE
DCOM- 19950316
LR  - 20061115
IS  - 0167-5699 (Print)
IS  - 0167-5699 (Linking)
VI  - 15
IP  - 12
DP  - 1994 Dec
TI  - Inflammatory cytokines in the brain: does the CNS shape immune responses?
PG  - 566-71
AB  - Immune responses in the central nervous system (CNS) have traditionally been 
      regarded as representing the intrusion of an unruly, ill-behaved mob of 
      leukocytes into the well-ordered and organized domain of thought and reason. 
      However, results accumulated over the past few years suggest that, far from being 
      an immunologically privileged organ, T lymphocytes may be regular and frequent 
      visitors to the CNS, for purposes of immune surveillance. Here, Trevor Owens and 
      colleagues propose that the brain itself can regulate or shape immune responses 
      therein. Furthermore, given that the immune cells may be subverted to 
      autoimmunity, they suggest that the study of inflammatory autoimmune disease in 
      the brain may shed light on the ability of the local environment to regulate 
      immune responses.
FAU - Owens, T
AU  - Owens T
AD  - Neuroimmunology Group, Montreal Neurological Institute, Quebec, Canada.
FAU - Renno, T
AU  - Renno T
FAU - Taupin, V
AU  - Taupin V
FAU - Krakowski, M
AU  - Krakowski M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Immunol Today
JT  - Immunology today
JID - 8008346
RN  - 0 (Cytokines)
SB  - IM
MH  - Animals
MH  - Antigen Presentation
MH  - Brain/*immunology
MH  - Cytokines/*physiology
MH  - Encephalitis/*immunology
MH  - Humans
MH  - T-Lymphocytes/immunology
RF  - 48
EDAT- 1994/12/01 00:00
MHDA- 1994/12/01 00:01
CRDT- 1994/12/01 00:00
PHST- 1994/12/01 00:00 [pubmed]
PHST- 1994/12/01 00:01 [medline]
PHST- 1994/12/01 00:00 [entrez]
AID - 0167-5699(94)90218-6 [pii]
AID - 10.1016/0167-5699(94)90218-6 [doi]
PST - ppublish
SO  - Immunol Today. 1994 Dec;15(12):566-71. doi: 10.1016/0167-5699(94)90218-6.