PMID- 7849089
OWN - NLM
STAT- MEDLINE
DCOM- 19950310
LR  - 20191101
IS  - 0893-9675 (Print)
IS  - 0893-9675 (Linking)
VI  - 5
IP  - 2-3
DP  - 1994
TI  - The tumor-promoting effect of wounding: a possible role for TGF-beta-induced 
      stromal alterations.
PG  - 297-311
AB  - From clinical, chemical carcinogenesis and transgenic animal studies, it is 
      evident that wounding has a tumor-promoting effect. We discuss the role of 
      TGF-beta (with special emphasis on TGF-beta 1) in this process and suggest that 
      stromal alterations during wound healing, induced by TGF-beta, can be an 
      important determinant of tumor growth. A tumor and a wound both require similar 
      stromal microenvironments. Thus, a chemically initiated or an oncogene-expressing 
      cell could be complemented to grow into a tumor if it finds itself in a 
      hospitable wound-healing stroma.
FAU - Sieweke, M H
AU  - Sieweke MH
AD  - Cell and Molecular Biology Department, University of California, Berkeley 94720.
FAU - Bissell, M J
AU  - Bissell MJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
PL  - United States
TA  - Crit Rev Oncog
JT  - Critical reviews in oncogenesis
JID - 8914610
RN  - 0 (Transforming Growth Factor beta)
SB  - IM
MH  - Animals
MH  - Cell Transformation, Neoplastic/*genetics
MH  - *Cocarcinogenesis
MH  - Humans
MH  - Mice
MH  - Neoplasms/*physiopathology
MH  - Transforming Growth Factor beta/genetics/*physiology
MH  - Wound Healing/*physiology
RF  - 167
EDAT- 1994/01/01 00:00
MHDA- 1994/01/01 00:01
CRDT- 1994/01/01 00:00
PHST- 1994/01/01 00:00 [pubmed]
PHST- 1994/01/01 00:01 [medline]
PHST- 1994/01/01 00:00 [entrez]
AID - 10.1615/critrevoncog.v5.i2-3.90 [doi]
PST - ppublish
SO  - Crit Rev Oncog. 1994;5(2-3):297-311. doi: 10.1615/critrevoncog.v5.i2-3.90.