PMID- 7866999
OWN - NLM
STAT- MEDLINE
DCOM- 19950330
LR  - 20091119
IS  - 0008-5472 (Print)
IS  - 0008-5472 (Linking)
VI  - 55
IP  - 5
DP  - 1995 Mar 1
TI  - Expression of the Met/hepatocyte growth factor receptor in human pancreatic 
      cancer.
PG  - 1129-38
AB  - The c-MET oncogene encodes the receptor for hepatocyte growth factor (HGF) 
      scatter factor, a multifunctional cytokine able to mediate morphogenesis as well 
      as invasive growth of epithelial cells. The c-MET-encoded receptor is detectable 
      only at low levels in the normal human exocrine pancreas, but it is up-regulated 
      in the majority of pancreatic ductal adenocarcinomas. The c-MET-encoded HGF 
      receptor is also overexpressed in a proportion of the panel of 31 human 
      pancreatic cancer cell lines examined, which have a range of different growth 
      properties and degrees of differentiation. In most cases the HGF receptor found 
      in the malignant cells has features of the normal receptor. When added to 
      pancreatic cancer cell lines, HGF triggers receptor phosphorylation and 
      stimulates cells to move and proliferate. In overexpressing cell lines, the 
      Met/HGF receptor is phosphorylated in the absence of endogenously produced or 
      exogenously added ligand. These data suggest that the Met/HGF receptor may be 
      involved in the growth and behavior of pancreatic cancer and may contribute to 
      the ductal phenotype of these tumors.
FAU - Di Renzo, M F
AU  - Di Renzo MF
AD  - Imperial Cancer Research Fund Oncology Unit, Royal Postgraduate Medical School, 
      Hammersmith Hospital, London, United Kingdom.
FAU - Poulsom, R
AU  - Poulsom R
FAU - Olivero, M
AU  - Olivero M
FAU - Comoglio, P M
AU  - Comoglio PM
FAU - Lemoine, N R
AU  - Lemoine NR
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Res
JT  - Cancer research
JID - 2984705R
RN  - 67256-21-7 (Hepatocyte Growth Factor)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-met)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
SB  - IM
GS  - MET
GS  - c-MET
MH  - Base Sequence
MH  - Cell Division/drug effects
MH  - Cell Movement/drug effects
MH  - Gene Expression
MH  - Glycosylation
MH  - Hepatocyte Growth Factor/pharmacology
MH  - Humans
MH  - In Situ Hybridization
MH  - Molecular Sequence Data
MH  - Pancreas/physiology
MH  - Pancreatic Neoplasms/*genetics/pathology/ultrastructure
MH  - Proto-Oncogene Proteins c-met
MH  - Receptor Protein-Tyrosine Kinases/*genetics/metabolism
MH  - Stimulation, Chemical
MH  - Tumor Cells, Cultured/drug effects
EDAT- 1995/03/01 00:00
MHDA- 1995/03/01 00:01
CRDT- 1995/03/01 00:00
PHST- 1995/03/01 00:00 [pubmed]
PHST- 1995/03/01 00:01 [medline]
PHST- 1995/03/01 00:00 [entrez]
PST - ppublish
SO  - Cancer Res. 1995 Mar 1;55(5):1129-38.