PMID- 7880609
OWN - NLM
STAT- MEDLINE
DCOM- 19950412
LR  - 20220321
IS  - 0959-8049 (Print)
IS  - 0959-8049 (Linking)
VI  - 30A
IP  - 12
DP  - 1994
TI  - Histological grade, perineural infiltration, tumour-infiltrating lymphocytes and 
      apoptosis as determinants of long-term prognosis in prostatic adenocarcinoma.
PG  - 1797-803
AB  - A series of 325 prostatic adenocarcinomas with a long-term clinical follow-up 
      were subjected to light microscopic analysis of histological prognostic factors, 
      including three grading systems (Gleason score, WHO grade, nuclear grade), 
      perineural infiltration of the tumour (PNI), tumour infiltrating lymphocytes 
      (TIL) and the presence of apoptotic cells (APO). All three histological 
      classifications correlated significantly with the prognosis, but in multivariate 
      analysis, the Gleason score was superior to the WHO grading or nuclear grading in 
      predicting patient survival. PNI was significantly related to poor 
      differentiation of the tumour, its progression and ominous disease outcome, 
      particularly in T1-2MO tumours. The density of TIL was independent of the tumour 
      differentiation, and absent or weak TIL were signs of a high risk of tumour 
      progression and of a fatal disease. Apoptotic cells were commonly detected in 
      poorly differentiated tumours and apoptosis was related to disease progression 
      and low survival probability. The results suggest that the Gleason score, PNI and 
      the density of TIL should be included in routine pathology reports, to be used by 
      clinicians while making therapeutic decisions in prostatic cancer.
FAU - Vesalainen, S
AU  - Vesalainen S
AD  - Department of Surgery, University of Kuopio, Finland.
FAU - Lipponen, P
AU  - Lipponen P
FAU - Talja, M
AU  - Talja M
FAU - Syrjanen, K
AU  - Syrjanen K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur J Cancer
JT  - European journal of cancer (Oxford, England : 1990)
JID - 9005373
SB  - IM
MH  - Adenocarcinoma/mortality/*pathology
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Apoptosis
MH  - Disease-Free Survival
MH  - Follow-Up Studies
MH  - Humans
MH  - Lymphocytes, Tumor-Infiltrating/*pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Invasiveness
MH  - Neurons/pathology
MH  - Prognosis
MH  - Prostatic Neoplasms/mortality/*pathology
MH  - Survival Analysis
EDAT- 1994/01/01 00:00
MHDA- 1994/01/01 00:01
CRDT- 1994/01/01 00:00
PHST- 1994/01/01 00:00 [pubmed]
PHST- 1994/01/01 00:01 [medline]
PHST- 1994/01/01 00:00 [entrez]
AID - 0959-8049(94)E0159-2 [pii]
AID - 10.1016/0959-8049(94)e0159-2 [doi]
PST - ppublish
SO  - Eur J Cancer. 1994;30A(12):1797-803. doi: 10.1016/0959-8049(94)e0159-2.