PMID- 7891133
OWN - NLM
STAT- MEDLINE
DCOM- 19950420
LR  - 20191101
IS  - 0270-6474 (Print)
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Linking)
VI  - 15
IP  - 3 Pt 1
DP  - 1995 Mar
TI  - Central projections of sensory neurons in the Drosophila embryo correlate with 
      sensory modality, soma position, and proneural gene function.
PG  - 1755-67
AB  - The peripheral nervous system (PNS) of the Drosophila embryo is especially suited 
      for investigating the specification of neuronal identity: the PNS consists of a 
      relatively simple but diverse set of individually identified sensory neurons; 
      mutants, including embryonic lethals, can be readily generated and analyzed; and 
      axon growth can potentially be followed from the earliest stages. We have 
      developed a staining method to reveal the central projections of the full set of 
      sensory neurons in the preterminal abdominal segments of the embryo. The sensory 
      neurons exhibit modality-specific axonal projections in the CNS. The axons of 
      external sense (es) organ neurons, primarily tactile in function, are restricted 
      to a particular region within each neuromere and exhibit a somatotopic mapping 
      within the CNS. The axons of stretch-receptive chordotonal (ch) organs project 
      into a discrete longitudinal fascicle. Sensory neurons with multiple-branched 
      dendrites (md neurons) project into a separate fascicle. A small number of md 
      neurons have distinctive dorsal-projecting axonal processes in the CNS. A 
      classification of sensory neurons based on their axon morphology correlates 
      closely with the identity of the proneural gene responsible for their generation, 
      suggesting that proneural genes play a central role in determining neuronal 
      identity in the PNS of the embryo.
FAU - Merritt, D J
AU  - Merritt DJ
AD  - Department of Zoology, University of New England, Amidale, New South Wales, 
      Australia.
FAU - Whitington, P M
AU  - Whitington PM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
SB  - IM
MH  - Animals
MH  - Axons/ultrastructure
MH  - Drosophila/*anatomy & histology/physiology
MH  - Embryo, Nonmammalian/*cytology/physiology
MH  - Genes/*physiology
MH  - Neural Pathways
MH  - Neurons, Afferent/*cytology/physiology
MH  - Peripheral Nerves/embryology/*physiology
PMC - PMC6578135
EDAT- 1995/03/01 00:00
MHDA- 1995/03/01 00:01
PMCR- 1995/09/01
CRDT- 1995/03/01 00:00
PHST- 1995/03/01 00:00 [pubmed]
PHST- 1995/03/01 00:01 [medline]
PHST- 1995/03/01 00:00 [entrez]
PHST- 1995/09/01 00:00 [pmc-release]
AID - 10.1523/JNEUROSCI.15-03-01755.1995 [doi]
PST - ppublish
SO  - J Neurosci. 1995 Mar;15(3 Pt 1):1755-67. doi: 10.1523/JNEUROSCI.15-03-01755.1995.