PMID- 7902202
OWN - NLM
STAT- MEDLINE
DCOM- 19931223
LR  - 20190620
IS  - 0008-543X (Print)
IS  - 0008-543X (Linking)
VI  - 72
IP  - 11
DP  - 1993 Dec 1
TI  - Overexpression of c-erbB-2 protein in gastric cancer. Its correlation with 
      long-term survival of patients.
PG  - 3179-84
AB  - BACKGROUND: Overexpression of c-erbB-2 protein in breast cancer has been reported 
      to be associated with poor prognosis. However, clinical significance of c-erbB-2 
      protein overexpression has not been demonstrated clearly in gastric cancer. 
      METHODS: Immunohistochemical reactivity to c-erbB-2 protein was examined in 
      formalin-fixed, paraffin-embedded tissue sections from patients with gastric 
      cancer. RESULTS: First, primary stomach cancers in 106 patients were examined. 
      Among 58 cases of papillary or well- to moderately differentiated tubular 
      adenocarcinoma, staining of c-erbB-2 protein was positive on the plasma membrane 
      of cancer cells in 8 cases (14%). Conversely, among 47 cases of poorly 
      differentiated adenocarcinoma or signet ring cell carcinoma, positive staining of 
      c-erbB-2 protein was detected in one case only (2%), where the histopathologic 
      type was poorly differentiated adenocarcinoma with a cohesive structure. Among 
      tubular adenocarcinomas, no significant association was shown between 
      overexpression of c-erbB-2 protein and the depth of tumor invasion, extent of 
      lymph node metastasis, or tumor location. To investigate the correlation between 
      the staining of c-erbB-2 protein and prognosis in gastric cancer, an additional 
      108 cases of papillary or well- to moderately differentiated tubular 
      adenocarcinoma invasive as far as the muscularis propria were examined 
      immunohistochemically for expression of c-erbB-2 protein. Twelve cases (11%) 
      showed positive staining on the plasma membrane, and their survival curve showed 
      a significantly poorer prognosis (P < 0.01). CONCLUSIONS: These results suggest 
      that overexpression of c-erbB-2 protein occurs selectively in cohesive gastric 
      cancer, and it can be considered an important prognostic indicator.
FAU - Uchino, S
AU  - Uchino S
AD  - Pathology Division, National Cancer Center Research Institute, Tokyo, Japan.
FAU - Tsuda, H
AU  - Tsuda H
FAU - Maruyama, K
AU  - Maruyama K
FAU - Kinoshita, T
AU  - Kinoshita T
FAU - Sasako, M
AU  - Sasako M
FAU - Saito, T
AU  - Saito T
FAU - Kobayashi, M
AU  - Kobayashi M
FAU - Hirohashi, S
AU  - Hirohashi S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer
JT  - Cancer
JID - 0374236
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Proto-Oncogene Proteins)
RN  - EC 2.7.10.1 (ErbB Receptors)
RN  - EC 2.7.10.1 (Receptor, ErbB-2)
SB  - IM
MH  - Adenocarcinoma/genetics/metabolism/pathology/secondary
MH  - Adenocarcinoma, Papillary/genetics/metabolism/pathology/secondary
MH  - Biomarkers, Tumor/analysis/biosynthesis/*genetics
MH  - Carcinoma, Signet Ring Cell/genetics/metabolism/pathology
MH  - Cell Membrane/metabolism/ultrastructure
MH  - ErbB Receptors/analysis/biosynthesis/*genetics
MH  - Follow-Up Studies
MH  - Gastric Mucosa/metabolism/pathology
MH  - *Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Lymphatic Metastasis/pathology
MH  - Neoplasm Invasiveness
MH  - Neoplasm Recurrence, Local
MH  - Prognosis
MH  - Proto-Oncogene Proteins/analysis/biosynthesis/*genetics
MH  - Receptor, ErbB-2
MH  - Stomach Neoplasms/genetics/*metabolism/pathology
MH  - Survival Rate
EDAT- 1993/12/01 00:00
MHDA- 1993/12/01 00:01
CRDT- 1993/12/01 00:00
PHST- 1993/12/01 00:00 [pubmed]
PHST- 1993/12/01 00:01 [medline]
PHST- 1993/12/01 00:00 [entrez]
AID - 10.1002/1097-0142(19931201)72:11<3179::aid-cncr2820721108>3.0.co;2-# [doi]
PST - ppublish
SO  - Cancer. 1993 Dec 1;72(11):3179-84. doi: 
      10.1002/1097-0142(19931201)72:11<3179::aid-cncr2820721108>3.0.co;2-#.