PMID- 7902379
OWN - NLM
STAT- MEDLINE
DCOM- 19940106
LR  - 20181130
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 151
IP  - 11
DP  - 1993 Dec 1
TI  - Targeting of T lymphocytes to Neu/HER2-expressing cells using chimeric single 
      chain Fv receptors.
PG  - 6577-82
AB  - Cell surface molecules essential for the transformed phenotype or growth of 
      malignant cells are attractive targets for anticancer immunotherapy. Antibodies 
      specific to Neu/HER2, a human adenocarcinoma-associated growth factor receptor, 
      were demonstrated to have tumor-inhibitory capacity. Yet, the inefficient 
      accessibility of antibodies to solid tumors limits their clinical use. To 
      redirect effector lymphocytes to adenocarcinomas, we constructed and functionally 
      expressed in T cells chimeric single chain receptor genes incorporating both the 
      Ag-binding domain of anti-Neu/HER2 antibodies and the zeta-signal-transducing 
      subunit of the TCR/CD3 complex or the gamma-signal-transducing subunit of the Ig 
      Fc receptor complex. Surface expression of the anti-Neu/HER2 chimeric genes in 
      cytotoxic T cell hybridomas endowed them with specific Neu/HER2 recognition 
      enabling their activation for IL-2 production and lysis of transformed cells 
      overexpressing Neu/HER2. These chimeric genes hold promise for the immunotherapy 
      of cancer.
FAU - Stancovski, I
AU  - Stancovski I
AD  - Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, 
      Israel.
FAU - Schindler, D G
AU  - Schindler DG
FAU - Waks, T
AU  - Waks T
FAU - Yarden, Y
AU  - Yarden Y
FAU - Sela, M
AU  - Sela M
FAU - Eshhar, Z
AU  - Eshhar Z
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Membrane Proteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Receptors, Antigen, T-Cell)
RN  - 0 (Receptors, Fc)
RN  - 0 (Recombinant Fusion Proteins)
RN  - 0 (antigen T cell receptor, zeta chain)
RN  - EC 2.7.10.1 (ErbB Receptors)
RN  - EC 2.7.10.1 (Receptor, ErbB-2)
SB  - IM
MH  - Animals
MH  - Antibodies, Monoclonal/*genetics
MH  - Cytotoxicity, Immunologic
MH  - ErbB Receptors/*immunology
MH  - Membrane Proteins/*genetics
MH  - Mice
MH  - Proto-Oncogene Proteins/*immunology
MH  - Receptor, ErbB-2
MH  - Receptors, Antigen, T-Cell/*genetics
MH  - Receptors, Fc/*genetics
MH  - Recombinant Fusion Proteins/*genetics
MH  - T-Lymphocytes/*immunology
MH  - Transfection
EDAT- 1993/12/01 00:00
MHDA- 1993/12/01 00:01
CRDT- 1993/12/01 00:00
PHST- 1993/12/01 00:00 [pubmed]
PHST- 1993/12/01 00:01 [medline]
PHST- 1993/12/01 00:00 [entrez]
PST - ppublish
SO  - J Immunol. 1993 Dec 1;151(11):6577-82.