PMID- 7905913
OWN - NLM
STAT- MEDLINE
DCOM- 19940317
LR  - 20190909
IS  - 0955-3002 (Print)
IS  - 0955-3002 (Linking)
VI  - 65
IP  - 1
DP  - 1994 Jan
TI  - Characterization of radiation-induced apoptosis in the small intestine and its 
      biological implications.
PG  - 71-8
AB  - The small intestine with its high cell proliferation, well-accepted hierarchy, 
      high radiation susceptibility and low cancer incidence is a useful model for 
      studying the controls of cell replacement. Apoptosis, which represents part of 
      the overall homeostatic process, occurs spontaneously at the stem cell position 
      in the crypts, and very small doses of radiation elevate the levels of apoptosis 
      rapidly in this region. Other cytotoxic agents also target cells in this region 
      including several mutagenic chemicals. Yet other drugs target cells at higher 
      positions in the crypt indicating that all crypt cells possess the programme for 
      apoptosis, but this is normally suppressed in many of the cells. In contrast, 
      high doses of radiation are required to reproductively sterilize the crypts and, 
      using clonal regeneration techniques, the number of clonogenic cells is dependent 
      on the levels of damage induced (dose), i.e. the more injury that is induced the 
      greater number of cells that are recruited into the clonogenic compartment. All 
      doses of radiation trigger rapid changes in proliferation in the stem cell region 
      which suggests that the detection of the induced cell death (even small levels, 
      such as one apoptotic cell per crypt) is efficient and has rapid consequences. 
      p53 may be involved in this damage recognition and apoptosis initiation. The 
      studies to date suggest that apoptosis plays an important role in this tissue in 
      terms of its homeostasis and its protection against carcinogenesis by removal of 
      potentially carcinogenic damaged cells.
FAU - Potten, C S
AU  - Potten CS
AD  - CRC Department of Epithelial Biology, Paterson Institute for Cancer Research, 
      Christie Hospital (NHS) Trust, Manchester, UK.
FAU - Merritt, A
AU  - Merritt A
FAU - Hickman, J
AU  - Hickman J
FAU - Hall, P
AU  - Hall P
FAU - Faranda, A
AU  - Faranda A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Int J Radiat Biol
JT  - International journal of radiation biology
JID - 8809243
SB  - IM
MH  - Animals
MH  - *Apoptosis
MH  - Intestine, Small/cytology/drug effects/*radiation effects
MH  - Mice
RF  - 34
EDAT- 1994/01/01 00:00
MHDA- 1994/01/01 00:01
CRDT- 1994/01/01 00:00
PHST- 1994/01/01 00:00 [pubmed]
PHST- 1994/01/01 00:01 [medline]
PHST- 1994/01/01 00:00 [entrez]
AID - F9XQXCV59JY5N1TQ [pii]
AID - 10.1080/09553009414550101 [doi]
PST - ppublish
SO  - Int J Radiat Biol. 1994 Jan;65(1):71-8. doi: 10.1080/09553009414550101.