PMID- 7910468
OWN - NLM
STAT- MEDLINE
DCOM- 19940623
LR  - 20240104
IS  - 0896-6273 (Print)
IS  - 0896-6273 (Linking)
VI  - 12
IP  - 5
DP  - 1994 May
TI  - The Drosophila sine oculis locus encodes a homeodomain-containing protein 
      required for the development of the entire visual system.
PG  - 977-96
AB  - The transformation of an unpatterned epithelium into a patterned one is a 
      fundamental issue in morphogenesis. This transformation occurs in a dramatic 
      fashion in the developing eye imaginal disc, the primordium of the Drosophila 
      compound eye. Molecular and developmental analyses reveals that the sine oculis 
      (so) locus encodes a homeodomain-containing protein that is expressed and 
      required in the unpatterned epithelium prior to morphogenesis. In mutants, cells 
      undergo apoptosis. These findings argue that so plays an essential role in 
      controlling the initial events of pattern formation in the eye disc. So is also 
      expressed and required for the development of the rest of the fly visual system, 
      including the optic lobes (i.e., those regions of the brain that process visual 
      information). So is expressed in the optic lobe primordium prior to its 
      invagination from the embryonic ectoderm; in so mutants, the optic lobe 
      primordium fails to invaginate.
FAU - Cheyette, B N
AU  - Cheyette BN
AD  - Molecular Biology Institute, University of California, School of Medicine, Los 
      Angeles 90024-1737.
FAU - Green, P J
AU  - Green PJ
FAU - Martin, K
AU  - Martin K
FAU - Garren, H
AU  - Garren H
FAU - Hartenstein, V
AU  - Hartenstein V
FAU - Zipursky, S L
AU  - Zipursky SL
LA  - eng
SI  - GENBANK/L31626
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Neuron
JT  - Neuron
JID - 8809320
RN  - 0 (Drosophila Proteins)
RN  - 0 (Eye Proteins)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (So protein, Drosophila)
RN  - 9007-49-2 (DNA)
SB  - IM
GS  - so
MH  - Alleles
MH  - Amino Acid Sequence
MH  - Animals
MH  - Apoptosis
MH  - Base Sequence
MH  - Cell Differentiation
MH  - Cell Division
MH  - DNA/chemistry/metabolism
MH  - Drosophila/*genetics
MH  - *Drosophila Proteins
MH  - Eye/cytology/*growth & development/ultrastructure
MH  - Eye Proteins/chemistry/*genetics
MH  - *Gene Expression
MH  - *Genes, Homeobox
MH  - *Homeodomain Proteins
MH  - Introns
MH  - Microscopy, Electron, Scanning
MH  - Molecular Sequence Data
MH  - Morphogenesis
MH  - *Mutation
MH  - Nervous System/growth & development
MH  - Nervous System Physiological Phenomena
MH  - Protein Structure, Secondary
MH  - Sequence Deletion
MH  - Sequence Homology, Amino Acid
MH  - Transcription, Genetic
MH  - Vision, Ocular/genetics
EDAT- 1994/05/01 00:00
MHDA- 1994/05/01 00:01
CRDT- 1994/05/01 00:00
PHST- 1994/05/01 00:00 [pubmed]
PHST- 1994/05/01 00:01 [medline]
PHST- 1994/05/01 00:00 [entrez]
AID - 0896-6273(94)90308-5 [pii]
AID - 10.1016/0896-6273(94)90308-5 [doi]
PST - ppublish
SO  - Neuron. 1994 May;12(5):977-96. doi: 10.1016/0896-6273(94)90308-5.