PMID- 7910974
OWN - NLM
STAT- MEDLINE
DCOM- 19940627
LR  - 20211203
IS  - 0165-1781 (Print)
IS  - 0165-1781 (Linking)
VI  - 51
IP  - 1
DP  - 1994 Jan
TI  - Serum interleukin-6 concentration in schizophrenia: elevation associated with 
      duration of illness.
PG  - 1-10
AB  - Using an enzyme immunoassay (ELISA), we measured serum interleukin-6 (IL-6) 
      concentration in 128 schizophrenic patients (24 of whom were never medicated) and 
      in 110 normal control subjects. Mean serum IL-6 concentration was significantly 
      higher in the schizophrenic patients as compared with the control subjects (p = 
      0.009). Comparisons within the patient group revealed that serum IL-6 was 
      significantly correlated with duration of illness (r = 0.32, p = 0.0004). After 
      covariation for duration of illness, there was no relationship between IL-6 
      levels and the production of autoantibodies, clinical state, or medication 
      status. Thus, elevated serum IL-6 levels in schizophrenia develop during the 
      course of illness and may be related to treatment or to disease progression.
FAU - Ganguli, R
AU  - Ganguli R
AD  - Department of Psychiatry, University of Pittsburgh School of Medicine, PA.
FAU - Yang, Z
AU  - Yang Z
FAU - Shurin, G
AU  - Shurin G
FAU - Chengappa, K N
AU  - Chengappa KN
FAU - Brar, J S
AU  - Brar JS
FAU - Gubbi, A V
AU  - Gubbi AV
FAU - Rabin, B S
AU  - Rabin BS
LA  - eng
GR  - MH-00710/MH/NIMH NIH HHS/United States
GR  - MH-41883/MH/NIMH NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Autoantibodies)
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-6)
SB  - IM
MH  - Adult
MH  - Antipsychotic Agents/administration & dosage/therapeutic use
MH  - Autoantibodies/immunology
MH  - Cytokines/immunology
MH  - Ethnicity
MH  - Female
MH  - Humans
MH  - Interleukin-6/*blood/immunology
MH  - Male
MH  - Schizophrenia/*blood/drug therapy/immunology
MH  - Sex Factors
EDAT- 1994/01/01 00:00
MHDA- 1994/01/01 00:01
CRDT- 1994/01/01 00:00
PHST- 1994/01/01 00:00 [pubmed]
PHST- 1994/01/01 00:01 [medline]
PHST- 1994/01/01 00:00 [entrez]
AID - 0165-1781(94)90042-6 [pii]
AID - 10.1016/0165-1781(94)90042-6 [doi]
PST - ppublish
SO  - Psychiatry Res. 1994 Jan;51(1):1-10. doi: 10.1016/0165-1781(94)90042-6.