PMID- 7916657 OWN - NLM STAT- MEDLINE DCOM- 19930820 LR - 20190705 IS - 0092-8674 (Print) IS - 0092-8674 (Linking) VI - 74 IP - 1 DP - 1993 Jul 16 TI - The Drosophila anachronism locus: a glycoprotein secreted by glia inhibits neuroblast proliferation. PG - 15-27 AB - The Drosophila anachronism (ana) locus controls the proliferation of neuroblasts, neuronal stem cells that give rise to the central nervous system. In ana mutants, quiescent postembryonic central brain and optic lobe neuroblasts enter S phase precociously. ana encodes a novel secreted protein of 474 amino acids that is expressed not in the affected neuroblasts, but rather in a subclass of neighboring glial cells. These studies argue for an important role for glia in negatively regulating proliferation of neuronal precursor cells, thereby controlling the timing of postembryonic neurogenesis. FAU - Ebens, A J AU - Ebens AJ AD - Howard Hughes Medical Institute, Department of Biological Chemistry, University of California, School of Medicine, Los Angeles 90024-1737. FAU - Garren, H AU - Garren H FAU - Cheyette, B N AU - Cheyette BN FAU - Zipursky, S L AU - Zipursky SL LA - eng SI - GENBANK/L14568 SI - GENBANK/L14569 SI - GENBANK/L22753 SI - GENBANK/L33709 SI - GENBANK/S60902 SI - GENBANK/S60903 SI - GENBANK/S60904 SI - GENBANK/S60905 SI - GENBANK/S60924 SI - GENBANK/S63815 GR - GM-07104/GM/NIGMS NIH HHS/United States PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, P.H.S. PL - United States TA - Cell JT - Cell JID - 0413066 RN - 0 (Drosophila Proteins) RN - 0 (Glycoproteins) RN - 0 (ana protein, Drosophila) SB - IM GS - ana MH - Amino Acid Sequence MH - Animals MH - Base Sequence MH - Brain/embryology MH - Cell Differentiation/drug effects MH - Cell Division/drug effects MH - Cells, Cultured/drug effects MH - DNA Mutational Analysis MH - Drosophila/embryology/*genetics MH - *Drosophila Proteins MH - Glycoproteins/*genetics/pharmacology MH - Molecular Sequence Data MH - Mutation MH - Neuroglia/*metabolism MH - Neurons/drug effects MH - Stem Cells/drug effects EDAT- 1993/07/16 00:00 MHDA- 1993/07/16 00:01 CRDT- 1993/07/16 00:00 PHST- 1993/07/16 00:00 [pubmed] PHST- 1993/07/16 00:01 [medline] PHST- 1993/07/16 00:00 [entrez] AID - 0092-8674(93)90291-W [pii] AID - 10.1016/0092-8674(93)90291-w [doi] PST - ppublish SO - Cell. 1993 Jul 16;74(1):15-27. doi: 10.1016/0092-8674(93)90291-w.