PMID- 7945146
OWN - NLM
STAT- MEDLINE
DCOM- 19941116
LR  - 20191210
IS  - 0163-1047 (Print)
IS  - 0163-1047 (Linking)
VI  - 62
IP  - 1
DP  - 1994 Jul
TI  - Effects of an exogenous beta-amyloid peptide on retention for spatial learning.
PG  - 60-7
AB  - Three experiments assessed the effects of beta-amyloid 1-40 (beta A4) on spatial 
      learning in Sprague-Dawley rats. In Experiment 1, rats were trained on a signaled 
      footshock avoidance in a Y-maze. Rats received a single injection of beta A4 or 
      vehicle in both sides of the hippocampus immediately after the fifth trial. The 
      beta A4 group took significantly longer than the vehicle group to learn to avoid 
      the shock when trained to criterion 1 week later, suggesting a detrimental effect 
      of beta A4 on memory consolidation. Experiment 2 used a food reinforcer rather 
      than shock relief under procedures similar to Experiment 1. Again, the beta A4 
      group took longer to learn the maze to criterion. This shocks that the effect in 
      Experiment 1 was not specific to shock-maintained learning. In Experiment 3, rats 
      were trained to retrieve a food pellet from each arm of an eight-arm radial maze. 
      After training to criterion, beta A4 or vehicle was administered 
      intrahippocampally 30 min before the daily session for 26 sessions. There were no 
      acute or chronic effects of beta A4 injection on radial maze performance, and no 
      aggregation of beta A4 or significant necrosis was observed upon postmortem 
      histological analysis. These experiments suggest that single injections of beta 
      A4 impair memory consolidation, but repeated injections of beta A4 over an 
      extended period do not affect well-learned behavior.
FAU - McDonald, M P
AU  - McDonald MP
AD  - Department of Psychology, University of Minnesota, Minneapolis 55455.
FAU - Dahl, E E
AU  - Dahl EE
FAU - Overmier, J B
AU  - Overmier JB
FAU - Mantyh, P
AU  - Mantyh P
FAU - Cleary, J
AU  - Cleary J
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Behav Neural Biol
JT  - Behavioral and neural biology
JID - 7905471
RN  - 0 (Amyloid beta-Peptides)
SB  - IM
MH  - Amyloid beta-Peptides/*pharmacology
MH  - Animals
MH  - Avoidance Learning/drug effects
MH  - Behavior, Animal/drug effects
MH  - Dose-Response Relationship, Drug
MH  - Hippocampus/drug effects
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reinforcement, Psychology
MH  - Retention, Psychology/*drug effects
MH  - Spatial Behavior/*drug effects
EDAT- 1994/07/01 00:00
MHDA- 1994/07/01 00:01
CRDT- 1994/07/01 00:00
PHST- 1994/07/01 00:00 [pubmed]
PHST- 1994/07/01 00:01 [medline]
PHST- 1994/07/01 00:00 [entrez]
AID - 10.1016/s0163-1047(05)80059-7 [doi]
PST - ppublish
SO  - Behav Neural Biol. 1994 Jul;62(1):60-7. doi: 10.1016/s0163-1047(05)80059-7.