PMID- 7949163
OWN - NLM
STAT- MEDLINE
DCOM- 19941129
LR  - 20210216
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 84
IP  - 9
DP  - 1994 Nov 1
TI  - Targeting of human immunodeficiency virus-infected cells by CD8+ T lymphocytes 
      armed with universal T-cell receptors.
PG  - 2878-89
AB  - We have developed an immunotherapeutic approach with potential application in the 
      treatment of viral and malignant disease. We show that primary CD8+ T cells 
      isolated from peripheral blood can be genetically modified by retroviral 
      transduction to express high levels of universal (major histocompatibility 
      complex-unrestricted) chimeric T-cell receptors specific for human 
      immunodeficiency virus (HIV) antigens. Two classes of HIV-specific URs in which 
      the antigen-binding domain is comprised of either CD4 or a single-chain antibody 
      are capable of activating a number of T-cell effector functions in response to 
      target cells, including cytolysis, in a highly sensitive and specific manner. 
      Importantly, we have addressed a number of issues which, although particularly 
      relevant to the clinical application of this approach in the treatment of HIV 
      infection, may also impact on the potential of UR immunotherapy for other disease 
      targets. The UR immunotherapeutic system is particularly suited for evaluation in 
      the clinical setting.
FAU - Roberts, M R
AU  - Roberts MR
AD  - Cell Genesys Inc, Foster City, CA.
FAU - Qin, L
AU  - Qin L
FAU - Zhang, D
AU  - Zhang D
FAU - Smith, D H
AU  - Smith DH
FAU - Tran, A C
AU  - Tran AC
FAU - Dull, T J
AU  - Dull TJ
FAU - Groopman, J E
AU  - Groopman JE
FAU - Capon, D J
AU  - Capon DJ
FAU - Byrn, R A
AU  - Byrn RA
FAU - Finer, M H
AU  - Finer MH
LA  - eng
GR  - 5U01-AI31686/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (Antigens, Viral)
RN  - 0 (HIV Antibodies)
RN  - 0 (HIV Envelope Protein gp120)
RN  - 0 (Receptors, Antigen, T-Cell)
RN  - 0 (Recombinant Fusion Proteins)
SB  - IM
MH  - Animals
MH  - Antigens, Viral/immunology
MH  - CD8-Positive T-Lymphocytes/*immunology
MH  - Cytotoxicity, Immunologic
MH  - HIV/*immunology
MH  - HIV Antibodies/immunology
MH  - HIV Envelope Protein gp120/immunology
MH  - HIV Infections/*therapy
MH  - Immunity, Cellular
MH  - Immunotherapy
MH  - In Vitro Techniques
MH  - Lymphocyte Activation
MH  - Receptors, Antigen, T-Cell/*immunology
MH  - Recombinant Fusion Proteins/immunology
EDAT- 1994/11/01 00:00
MHDA- 1994/11/01 00:01
CRDT- 1994/11/01 00:00
PHST- 1994/11/01 00:00 [pubmed]
PHST- 1994/11/01 00:01 [medline]
PHST- 1994/11/01 00:00 [entrez]
AID - S0006-4971(20)71299-1 [pii]
PST - ppublish
SO  - Blood. 1994 Nov 1;84(9):2878-89.