PMID- 7954427
OWN - NLM
STAT- MEDLINE
DCOM- 19941202
LR  - 20071114
IS  - 0008-5472 (Print)
IS  - 0008-5472 (Linking)
VI  - 54
IP  - 22
DP  - 1994 Nov 15
TI  - Loss of Apc+ in intestinal adenomas from Min mice.
PG  - 5947-52
AB  - Allelic loss at the Apc locus in spontaneously occurring intestinal adenomas from 
      mice heterozygous for the ApcMin nonsense mutation was analyzed using a 
      site-specific quantitative polymerase chain reaction assay. All 97 of the 
      intestinal adenomas analyzed showed extensive loss of the wild-type Apc (Apc+) 
      allele. Quantitative polymerase chain reaction analysis of loci linked to Apc 
      indicated loss of the chromosome carrying Apc+. Only one copy of the homologue 
      carrying ApcMin remained in the intestinal adenomas. Possible reasons for the 
      difference in the mechanism of Apc+ loss between human and Min mouse intestinal 
      adenomas are discussed.
FAU - Luongo, C
AU  - Luongo C
AD  - McArdle Laboratory for Cancer Research, University of Wisconsin Medical School, 
      Madison 53706.
FAU - Moser, A R
AU  - Moser AR
FAU - Gledhill, S
AU  - Gledhill S
FAU - Dove, W F
AU  - Dove WF
LA  - eng
GR  - P01-23076/PHS HHS/United States
GR  - R01-63677/PHS HHS/United States
GR  - R01-CA50585/CA/NCI NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cancer Res
JT  - Cancer research
JID - 2984705R
RN  - 0 (DNA Probes)
SB  - IM
GS  - Apc
GS  - Apc<up>Min</up>
MH  - Adenoma/*genetics
MH  - Animals
MH  - Base Sequence
MH  - Chromosome Mapping
MH  - Colonic Neoplasms/genetics
MH  - DNA Probes/genetics
MH  - Female
MH  - *Gene Deletion
MH  - Genes, APC/*genetics
MH  - Intestinal Neoplasms/*genetics
MH  - Intestine, Small
MH  - Male
MH  - Mice
MH  - Mice, Inbred AKR
MH  - Molecular Sequence Data
MH  - Polymerase Chain Reaction
EDAT- 1994/11/15 00:00
MHDA- 1994/11/15 00:01
CRDT- 1994/11/15 00:00
PHST- 1994/11/15 00:00 [pubmed]
PHST- 1994/11/15 00:01 [medline]
PHST- 1994/11/15 00:00 [entrez]
PST - ppublish
SO  - Cancer Res. 1994 Nov 15;54(22):5947-52.