PMID- 7958896
OWN - NLM
STAT- MEDLINE
DCOM- 19941207
LR  - 20211203
IS  - 0890-9369 (Print)
IS  - 0890-9369 (Linking)
VI  - 8
IP  - 19
DP  - 1994 Oct 1
TI  - Transcriptional enhancer factor 1 disruption by a retroviral gene trap leads to 
      heart defects and embryonic lethality in mice.
PG  - 2293-301
AB  - We have used a retroviral gene trap in embryonic stem (ES) cells to derive a 
      recessive embryonic lethal mouse strain, ROSA beta-geo5. Mutant embryos display 
      an enlarged pericardial cavity, bradycardia, a dilated fourth ventricle in the 
      brain, and die between embryonic days 11 and 12. Whereas heart development in the 
      mutant embryos is extensive, the ventricular wall is abnormally thin with a 
      reduced number of trabeculae. Cloning of the trapped gene indicates that proviral 
      insertion creates a null mutation in the transcriptional enhancer factor 1 
      (TEF-1) gene. Although transcription of a number of muscle-specific genes 
      believed to be TEF-1 targets appears normal, the defect in cardiogenesis is 
      likely attributable to diminished transcription of one or several 
      cardiac-specific genes.
FAU - Chen, Z
AU  - Chen Z
AD  - Program in Molecular Medicine, Fred Hutchinson Cancer Research Center, Seattle, 
      Washington 98104.
FAU - Friedrich, G A
AU  - Friedrich GA
FAU - Soriano, P
AU  - Soriano P
LA  - eng
SI  - GENBANK/S74227
GR  - HD24875/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genes Dev
JT  - Genes & development
JID - 8711660
RN  - 0 (DNA Primers)
RN  - 0 (DNA, Complementary)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (TEA Domain Transcription Factors)
RN  - 0 (TEAD1 protein, human)
RN  - 0 (Transcription Factors)
SB  - IM
GS  - TEF-1
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Cloning, Molecular
MH  - DNA Primers/genetics
MH  - DNA, Complementary/genetics
MH  - DNA-Binding Proteins/*genetics
MH  - Embryo, Mammalian/cytology
MH  - Female
MH  - Fetal Death/genetics
MH  - *Genes, Lethal
MH  - Heart Defects, Congenital/*genetics
MH  - Male
MH  - Mice
MH  - Mice, Mutant Strains
MH  - Molecular Sequence Data
MH  - Mutation
MH  - *Nuclear Proteins
MH  - Retroviridae/genetics
MH  - Stem Cells
MH  - TEA Domain Transcription Factors
MH  - Transcription Factors/*genetics
EDAT- 1994/10/01 00:00
MHDA- 1994/10/01 00:01
CRDT- 1994/10/01 00:00
PHST- 1994/10/01 00:00 [pubmed]
PHST- 1994/10/01 00:01 [medline]
PHST- 1994/10/01 00:00 [entrez]
AID - 10.1101/gad.8.19.2293 [doi]
PST - ppublish
SO  - Genes Dev. 1994 Oct 1;8(19):2293-301. doi: 10.1101/gad.8.19.2293.