PMID- 7959869
OWN - NLM
STAT- MEDLINE
DCOM- 19941130
LR  - 20181113
IS  - 0019-2805 (Print)
IS  - 1365-2567 (Electronic)
IS  - 0019-2805 (Linking)
VI  - 82
IP  - 3
DP  - 1994 Jul
TI  - Tissue-specific suppressor T cells involved in self-tolerance are activated 
      extrathymically by self-antigens.
PG  - 365-9
AB  - Autoimmune prostatitis developed spontaneously in (C57BL/6N x A/J)F1 (B6A) mice, 
      when thymectomy (Tx) was conducted on day 3 after birth (Tx-3). The lesion could 
      be prevented by a single injection of CD4+ spleen cells (4 x 10(6)) from normal 
      males, but not from normal females or newborn orchidectomized (Orx-0) mice. 
      However, when spleen cells were obtained from Orx-0 mice that had received a 
      dihydrotestosterone (DHT) pellet when adult to develop a mature prostate, 
      prostatitis could be prevented, suggesting that immune tolerance to prostate 
      antigen(s) is maintained by a CD4+ tissue-specific suppressor T cell (Ts) 
      population(s), which is activated by a specific autoantigen(s) in the mature 
      prostate. The result that even CD4+ cells from Orx-0 mice that were thymectomized 
      as adults and treated thereafter with DHT were effective for prevention of 
      prostatitis suggests that activation of this Ts population takes place in the 
      peripheral lymphoid organs, and that it maintains peripheral tolerance to 
      autoantigen in the prostate of these mice and probably also in normal mice.
FAU - Taguchi, O
AU  - Taguchi O
AD  - Laboratory of Experimental Pathology, Aichi Cancer Center Research Institute, 
      Nagoya, Japan.
FAU - Kontani, K
AU  - Kontani K
FAU - Ikeda, H
AU  - Ikeda H
FAU - Kezuka, T
AU  - Kezuka T
FAU - Takeuchi, M
AU  - Takeuchi M
FAU - Takahashi, T
AU  - Takahashi T
FAU - Takahashi, T
AU  - Takahashi T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Immunology
JT  - Immunology
JID - 0374672
RN  - 0 (Autoantibodies)
RN  - 0 (Autoantigens)
SB  - IM
MH  - Animals
MH  - Autoantibodies/biosynthesis
MH  - Autoantigens/*immunology
MH  - Autoimmune Diseases/*immunology
MH  - Female
MH  - Immune Tolerance/*immunology
MH  - Lymphocyte Activation/immunology
MH  - Male
MH  - Mice
MH  - Mice, Inbred A
MH  - Mice, Inbred C57BL
MH  - Prostate/immunology
MH  - Prostatitis/*immunology
MH  - Spleen/immunology
MH  - T-Lymphocytes, Regulatory/*immunology
MH  - Thymus Gland/immunology
PMC - PMC1414875
EDAT- 1994/07/01 00:00
MHDA- 1994/07/01 00:01
PMCR- 1995/07/01
CRDT- 1994/07/01 00:00
PHST- 1994/07/01 00:00 [pubmed]
PHST- 1994/07/01 00:01 [medline]
PHST- 1994/07/01 00:00 [entrez]
PHST- 1995/07/01 00:00 [pmc-release]
PST - ppublish
SO  - Immunology. 1994 Jul;82(3):365-9.