PMID- 8047282
OWN - NLM
STAT- MEDLINE
DCOM- 19940901
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 169
IP  - 1-2
DP  - 1994 Mar 14
TI  - Striatal G-proteins: effects of unilateral 6-hydroxydopamine lesions.
PG  - 195-8
AB  - To investigate the molecular mechanisms of denervation-induced dopamine receptor 
      supersensitivity, levels of striatal G-proteins were examined in 
      6-hydroxydopamine (6-OHDA)-lesioned rats. Increased levels of the alpha-subunits 
      of Gs and G(olf), as measured by immunoblotting, were observed 8 days postlesion 
      and remained elevated up to day 28 (25-45% over the time course). G(i) levels 
      were significantly increased only on day 8 (20%) and G(o) levels remained 
      unaltered. These results suggest that stimulatory G-proteins may be involved in 
      the long-term maintenance of dopamine receptor supersensitivity following 
      denervation.
FAU - Marcotte, E R
AU  - Marcotte ER
AD  - Department of Psychiatry, McMaster University, Hamilton, Ont., Canada.
FAU - Sullivan, R M
AU  - Sullivan RM
FAU - Mishra, R K
AU  - Mishra RK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Receptors, Dopamine D1)
RN  - 8HW4YBZ748 (Oxidopamine)
RN  - EC 3.6.1.- (GTP-Binding Proteins)
SB  - IM
MH  - Animals
MH  - GTP-Binding Proteins/immunology/*metabolism
MH  - Immunoblotting
MH  - Male
MH  - Neostriatum/drug effects/*metabolism
MH  - Oxidopamine/*toxicity
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Dopamine D1/drug effects
EDAT- 1994/03/14 00:00
MHDA- 1994/03/14 00:01
CRDT- 1994/03/14 00:00
PHST- 1994/03/14 00:00 [pubmed]
PHST- 1994/03/14 00:01 [medline]
PHST- 1994/03/14 00:00 [entrez]
AID - 0304-3940(94)90390-5 [pii]
AID - 10.1016/0304-3940(94)90390-5 [doi]
PST - ppublish
SO  - Neurosci Lett. 1994 Mar 14;169(1-2):195-8. doi: 10.1016/0304-3940(94)90390-5.