PMID- 8126091
OWN - NLM
STAT- MEDLINE
DCOM- 19940411
LR  - 20220215
IS  - 0021-9533 (Print)
IS  - 0021-9533 (Linking)
VI  - 106 ( Pt 4)
DP  - 1993 Dec
TI  - The cdc25 homologue twine is required for only some aspects of the entry into 
      meiosis in Drosophila.
PG  - 1035-44
AB  - The twineHB5 mutation prevents spindle formation during the entry into meiosis in 
      Drosophila males, but chromosome condensation and nuclear envelope breakdown both 
      still occur. This suggests the possibility that this particular cdc25 homologue 
      is required to activate a p34cdc2 kinase required for only some of the events of 
      this G2-M transition. In contrast, meiotic spindles do form in twineHB5 females, 
      although these appear abnormal. However, the female meiotic divisions do not 
      arrest at metaphase I as in wild type, but continue repeatedly, leading to gross 
      non-disjunction. Small chromatin masses, corresponding in size to the fourth 
      chromosomes, often segregate properly to the spindle poles. These can persist 
      into the embryos derived from twineHB5 females, where they appear to participate 
      in mitotic divisions on thin spindles. In addition, these embryos contain a small 
      number of large chromatin masses that are not associated with spindles.
FAU - White-Cooper, H
AU  - White-Cooper H
AD  - Department of Anatomy and Physiology, Medical Sciences Institute, University of 
      Dundee, Scotland, UK.
FAU - Alphey, L
AU  - Alphey L
FAU - Glover, D M
AU  - Glover DM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Cell Sci
JT  - Journal of cell science
JID - 0052457
RN  - 0 (Drosophila Proteins)
RN  - 0 (Insect Proteins)
RN  - 0 (Proteins)
RN  - 0 (twe protein, Drosophila)
RN  - EC 3.1.3.48 (cdc25 Phosphatases)
SB  - IM
MH  - Animals
MH  - *Drosophila Proteins
MH  - Drosophila melanogaster/*embryology/genetics
MH  - Female
MH  - Fertilization
MH  - *Insect Proteins
MH  - Male
MH  - Meiosis/genetics/*physiology
MH  - Nuclear Envelope/physiology
MH  - Oocytes/physiology
MH  - Proteins/*genetics/*physiology
MH  - Sequence Homology
MH  - Spindle Apparatus/physiology
MH  - cdc25 Phosphatases
EDAT- 1993/12/01 00:00
MHDA- 1993/12/01 00:01
CRDT- 1993/12/01 00:00
PHST- 1993/12/01 00:00 [pubmed]
PHST- 1993/12/01 00:01 [medline]
PHST- 1993/12/01 00:00 [entrez]
AID - 10.1242/jcs.106.4.1035 [doi]
PST - ppublish
SO  - J Cell Sci. 1993 Dec;106 ( Pt 4):1035-44. doi: 10.1242/jcs.106.4.1035.