PMID- 8199193
OWN - NLM
STAT- MEDLINE
DCOM- 19940707
LR  - 20220408
IS  - 0006-3002 (Print)
IS  - 0006-3002 (Linking)
VI  - 1198
IP  - 1
DP  - 1994 May 27
TI  - Cadherin expression in carcinomas: role in the formation of cell junctions and 
      the prevention of invasiveness.
PG  - 11-26
AB  - It has been realized that the loss of epithelial differentiation in carcinomas, 
      which is accompanied by higher mobility and invasiveness of the tumor cells, is 
      often a consequence of reduced intercellular adhesion. A variety of recent 
      reports have indicated that the primary cause for the 'scattering' of the cells 
      in invasive carcinomas is a disturbance of the integrity of intercellular 
      junctions, often involving loss of a functional cell-cell adhesion molecule 
      E-cadherin. It has also been suggested that during invasion, carcinoma cells 
      convert to a sort of mesenchymal stage, as do normal epithelial cells during 
      development. In the present review, permanent and transient molecular mechanisms 
      are discussed which lead to the impairment of junction integrity of the 
      epithelial cells and thus to the progression of carcinomas towards a more 
      metastatic state. Furthermore, the now extensive literature on the 
      down-regulation of E-cadherin expression in human and animal carcinomas is 
      reviewed in detail.
FAU - Birchmeier, W
AU  - Birchmeier W
AD  - Max-Delbruck-Centrum, Berlin, Germany.
FAU - Behrens, J
AU  - Behrens J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - Biochim Biophys Acta
JT  - Biochimica et biophysica acta
JID - 0217513
RN  - 0 (Cadherins)
SB  - IM
MH  - Animals
MH  - Cadherins/*biosynthesis/physiology
MH  - Carcinoma/*metabolism/*pathology
MH  - *Cell Adhesion
MH  - Humans
MH  - *Neoplasm Invasiveness
RF  - 180
EDAT- 1994/05/27 00:00
MHDA- 1994/05/27 00:01
CRDT- 1994/05/27 00:00
PHST- 1994/05/27 00:00 [pubmed]
PHST- 1994/05/27 00:01 [medline]
PHST- 1994/05/27 00:00 [entrez]
AID - 0304-419X(94)90003-5 [pii]
AID - 10.1016/0304-419x(94)90003-5 [doi]
PST - ppublish
SO  - Biochim Biophys Acta. 1994 May 27;1198(1):11-26. doi: 
      10.1016/0304-419x(94)90003-5.