PMID- 8207839
OWN - NLM
STAT- MEDLINE
DCOM- 19940713
LR  - 20231120
IS  - 0022-538X (Print)
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Linking)
VI  - 68
IP  - 7
DP  - 1994 Jul
TI  - Temporal association of cellular immune responses with the initial control of 
      viremia in primary human immunodeficiency virus type 1 syndrome.
PG  - 4650-5
AB  - Virologic and immunologic studies were performed on five patients presenting with 
      primary human immunodeficiency virus type 1 (HIV-1) infection. CD8+ cytotoxic T 
      lymphocyte (CTL) precursors specific for cells expressing antigens of HIV-1 Gag, 
      Pol, and Env were detected at or within 3 weeks of presentation in four of the 
      five patients and were detected in all five patients by 3 to 6 months after 
      presentation. The one patient with an absent initial CTL response had prolonged 
      symptoms, persistent viremia, and low CD4+ T-cell count. Neutralizing antibody 
      activity was absent at the time of presentation in all five patients. These 
      findings suggest that cellular immunity is involved in the initial control of 
      virus replication in primary HIV-1 infection and indicate a role for CTL in 
      protective immunity to HIV-1 in vivo.
FAU - Koup, R A
AU  - Koup RA
AD  - Aaron Diamond AIDS Research Center, New York University School of Medicine, New 
      York 10016.
FAU - Safrit, J T
AU  - Safrit JT
FAU - Cao, Y
AU  - Cao Y
FAU - Andrews, C A
AU  - Andrews CA
FAU - McLeod, G
AU  - McLeod G
FAU - Borkowsky, W
AU  - Borkowsky W
FAU - Farthing, C
AU  - Farthing C
FAU - Ho, D D
AU  - Ho DD
LA  - eng
GR  - AI 24030/AI/NIAID NIH HHS/United States
GR  - AI 24239/AI/NIAID NIH HHS/United States
GR  - AI 25541/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - 0 (HIV Antibodies)
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/blood/*immunology/microbiology
MH  - HIV Antibodies/analysis
MH  - HIV-1/immunology
MH  - Humans
MH  - Neutralization Tests
MH  - T-Lymphocytes, Cytotoxic/*immunology
MH  - Time Factors
MH  - Viremia/*immunology
PMC - PMC236393
EDAT- 1994/07/01 00:00
MHDA- 1994/07/01 00:01
PMCR- 1994/07/01
CRDT- 1994/07/01 00:00
PHST- 1994/07/01 00:00 [pubmed]
PHST- 1994/07/01 00:01 [medline]
PHST- 1994/07/01 00:00 [entrez]
PHST- 1994/07/01 00:00 [pmc-release]
AID - 10.1128/JVI.68.7.4650-4655.1994 [doi]
PST - ppublish
SO  - J Virol. 1994 Jul;68(7):4650-5. doi: 10.1128/JVI.68.7.4650-4655.1994.