PMID- 8223245
OWN - NLM
STAT- MEDLINE
DCOM- 19931129
LR  - 20220215
IS  - 0950-1991 (Print)
IS  - 0950-1991 (Linking)
VI  - 117
IP  - 1
DP  - 1993 Jan
TI  - The Drosophila gene pointed encodes two ETS-like proteins which are involved in 
      the development of the midline glial cells.
PG  - 163-76
AB  - Glial-neuronal cell interactions at the ventral midline are necessary for the 
      proper elaboration of commissures in the embryonic CNS of Drosophila. In 
      particular, migrating midline glial cells are required for the separation of 
      segmental commissures. During this process the glial cells recognize specific 
      neuronal cells at the midline, they migrate posteriorly along their cell 
      processes and thereby separate the segmental commissures. The gene pointed (pnt) 
      is required for this glial-neuronal cell interaction, as loss of function 
      mutations lead to a change in the migration behavior of the midline glial cells. 
      As a consequence, anterior and posterior commissures do not become separated and 
      appear fused. Molecular analysis of pointed has revealed two differently spliced 
      types of transcripts, which are encoded in a region extending over 55 kb of 
      genomic sequence. In the CNS both transcript classes are expressed in cells of 
      the midline, including the midline glial cells. Sequence analysis of cDNA clones 
      corresponding to both transcript types reveals two different pointed proteins 
      which share an ETS domain common to a number of transcription factors related to 
      the vertebrate ets oncogene. Furthermore, one pointed protein form contains an 
      additional domain of homology of approx. 80 amino acids in length, which is 
      shared by only a subset of the ETS protein family.
FAU - Klambt, C
AU  - Klambt C
AD  - Institut fur Entwicklungsbiologie, Koln, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Development
JT  - Development (Cambridge, England)
JID - 8701744
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Transcription Factors)
RN  - 0 (pnt protein, Drosophila)
SB  - IM
GS  - pnt
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Central Nervous System/*embryology
MH  - DNA-Binding Proteins
MH  - Drosophila/*genetics
MH  - Drosophila Proteins
MH  - Embryonic Induction/*genetics
MH  - Genes, Insect
MH  - In Situ Hybridization
MH  - Molecular Sequence Data
MH  - Morphogenesis/genetics
MH  - Nerve Tissue Proteins
MH  - Neuroglia/*physiology
MH  - Phenotype
MH  - Proto-Oncogene Proteins/*genetics
MH  - Sequence Homology, Amino Acid
MH  - Transcription Factors
MH  - Transcription, Genetic/genetics
EDAT- 1993/01/01 00:00
MHDA- 1993/01/01 00:01
CRDT- 1993/01/01 00:00
PHST- 1993/01/01 00:00 [pubmed]
PHST- 1993/01/01 00:01 [medline]
PHST- 1993/01/01 00:00 [entrez]
AID - 10.1242/dev.117.1.163 [doi]
PST - ppublish
SO  - Development. 1993 Jan;117(1):163-76. doi: 10.1242/dev.117.1.163.