PMID- 8260894
OWN - NLM
STAT- MEDLINE
DCOM- 19940125
LR  - 20190116
IS  - 1042-8194 (Print)
IS  - 1026-8022 (Linking)
VI  - 11
IP  - 3-4
DP  - 1993 Oct
TI  - L-myc and N-myc in hematopoietic malignancies.
PG  - 197-205
AB  - The myc proto-oncogenes encode nuclear DNA-binding phosphoproteins which regulate 
      cell proliferation and differentiation. The c-myc gene is implicated in 
      hematopoietic malignancies on the basis of its frequent deregulation in naturally 
      occurring leukemias and lymphomas. Recent evidence suggests that also the N-myc 
      and L-myc genes may have a role in normal and malignant hematopoiesis. N-myc and 
      to a certain degree L-myc can substitute for c-myc in transformation assays in 
      vitro, and their overexpression can block the differentiation of leukemia cell 
      lines. Immunoglobulin heavy chain enhancer (IgH) -driven overexpression of N-myc 
      or L-myc genes cause lymphatic and myeloid tumors, respectively, in transgenic 
      mice. Furthermore, the L-myc and N-myc genes are expressed in several human 
      leukemias and leukemia cell lines, L-myc predominantly in myeloid and N-myc both 
      in myeloid and in some lymphoid leukemias. All N/L-myc positive leukemias and 
      leukemia cell lines coexpress the c-myc gene, thus exemplifying a lack of 
      negative cross-regulation between the different myc genes in leukemia cells. 
      Taken together, these data suggest that L-myc and N-myc may participate in the 
      growth regulation of hematopoietic cells.
FAU - Hirvonen, H
AU  - Hirvonen H
AD  - Department of Medical Biochemistry, University of Turku, Finland.
FAU - Hukkanen, V
AU  - Hukkanen V
FAU - Salmi, T T
AU  - Salmi TT
FAU - Pelliniemi, T T
AU  - Pelliniemi TT
FAU - Alitalo, R
AU  - Alitalo R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
RN  - 0 (Proto-Oncogene Proteins c-myc)
RN  - 0 (RNA, Messenger)
SB  - IM
GS  - L-myc
GS  - N-myc
MH  - Animals
MH  - Gene Expression Regulation, Neoplastic
MH  - *Genes, myc
MH  - Humans
MH  - Leukemia/*genetics
MH  - Lymphoma/*genetics
MH  - Proto-Oncogene Proteins c-myc/physiology
MH  - RNA, Messenger/metabolism
RF  - 100
EDAT- 1993/10/01 00:00
MHDA- 1993/10/01 00:01
CRDT- 1993/10/01 00:00
PHST- 1993/10/01 00:00 [pubmed]
PHST- 1993/10/01 00:01 [medline]
PHST- 1993/10/01 00:00 [entrez]
AID - 10.3109/10428199309086996 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 1993 Oct;11(3-4):197-205. doi: 10.3109/10428199309086996.