PMID- 8269855
OWN - NLM
STAT- MEDLINE
DCOM- 19940203
LR  - 20220215
IS  - 0950-1991 (Print)
IS  - 0950-1991 (Linking)
VI  - 118
IP  - 4
DP  - 1993 Aug
TI  - Expanded: a gene involved in the control of cell proliferation in imaginal discs.
PG  - 1291-301
AB  - The expanded gene was first identified by a spontaneous mutation that causes 
      broad wings. We have identified an enhancer-trap insertion within expanded and 
      used it to generate additional mutations, including one null allele. expanded is 
      an essential gene, necessary for proper growth control of imaginal discs and, 
      when mutant, causes either hyperplasia or degeneration depending on the disc. 
      Wing overgrowth in expanded hypermorphs is limited to specific regions along the 
      anterior-posterior and dorsal-ventral axis. expanded encodes a novel 1429 amino 
      acid protein that is localized to the apical surface of disc cells and contains 
      three potential SH3-binding sites. Together, these observations suggest that the 
      Expanded protein engages in protein-protein interactions regulating cell 
      proliferation in discs.
FAU - Boedigheimer, M
AU  - Boedigheimer M
AD  - Laboratory of Genetics, University of Wisconsin, Madison 53706.
FAU - Laughon, A
AU  - Laughon A
LA  - eng
SI  - GENBANK/L09730
SI  - GENBANK/L13313
SI  - GENBANK/L13314
SI  - GENBANK/L13315
SI  - GENBANK/L13316
SI  - GENBANK/L14768
SI  - GENBANK/L16795
SI  - GENBANK/M62873
SI  - GENBANK/S66810
SI  - GENBANK/X57485
GR  - GM07133/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Development
JT  - Development (Cambridge, England)
JID - 8701744
RN  - 0 (Drosophila Proteins)
RN  - 0 (Insect Hormones)
RN  - 0 (Membrane Proteins)
RN  - 0 (ex protein, Drosophila)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Drosophila/embryology/*genetics
MH  - *Drosophila Proteins
MH  - Genes, Tumor Suppressor/*genetics
MH  - Insect Hormones/*genetics
MH  - *Membrane Proteins
MH  - Molecular Sequence Data
MH  - Morphogenesis/genetics
MH  - Mutation/genetics
MH  - Phenotype
MH  - Wings, Animal/anatomy & histology/*embryology
EDAT- 1993/08/01 00:00
MHDA- 1993/08/01 00:01
CRDT- 1993/08/01 00:00
PHST- 1993/08/01 00:00 [pubmed]
PHST- 1993/08/01 00:01 [medline]
PHST- 1993/08/01 00:00 [entrez]
AID - 10.1242/dev.118.4.1291 [doi]
PST - ppublish
SO  - Development. 1993 Aug;118(4):1291-301. doi: 10.1242/dev.118.4.1291.