PMID- 8270864
OWN - NLM
STAT- MEDLINE
DCOM- 19940202
LR  - 20190508
IS  - 0022-1007 (Print)
IS  - 1540-9538 (Electronic)
IS  - 0022-1007 (Linking)
VI  - 179
IP  - 1
DP  - 1994 Jan 1
TI  - The conditions of primary infection define the load of latent viral genome in 
      organs and the risk of recurrent cytomegalovirus disease.
PG  - 185-93
AB  - Recurrence of cytomegalovirus (CMV) from latency is a frequent cause of disease 
      in immunocompromised patients. To date, there is no explanation for the diversity 
      in the clinical manifestations. Primary infection can occur perinatally or later 
      in life, and inevitably results in latent infection. Seropositivity for 
      antibodies against CMV is indicative of latent infection, but is insufficient as 
      a predictor for the risk of recurrence. As a model for this important medical 
      problem, we compared the risks of murine CMV recurrence from latency established 
      after neonatal primary infection and after infection at adult age. The risk of 
      CMV recurrence was high only after neonatal infection. The copy number of latent 
      viral genome in tissues was identified as the key parameter that determines the 
      overall and organ-specific risks of recurrence. Latent CMV burden and risk of 
      recurrence were related to the extent of virus multiplication during primary 
      infection. The presence of latent CMV in multiple organs provides the molecular 
      basis for stochastic events of recurrence in single organs or in any combination 
      thereof. These findings are discussed as a concept of multifocal CMV latency and 
      recurrence. It provides a rationale for the diversity in the clinical outcome of 
      CMV disease.
FAU - Reddehase, M J
AU  - Reddehase MJ
AD  - Department of Virology, University of Ulm, Germany.
FAU - Balthesen, M
AU  - Balthesen M
FAU - Rapp, M
AU  - Rapp M
FAU - Jonjic, S
AU  - Jonjic S
FAU - Pavic, I
AU  - Pavic I
FAU - Koszinowski, U H
AU  - Koszinowski UH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Exp Med
JT  - The Journal of experimental medicine
JID - 2985109R
RN  - 0 (Antibodies, Viral)
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Animals
MH  - Antibodies, Viral/blood
MH  - Cytomegalovirus/genetics/isolation & purification/*physiology
MH  - Cytomegalovirus Infections/immunology/*microbiology
MH  - DNA, Viral/*isolation & purification
MH  - Disease Models, Animal
MH  - Female
MH  - Genome, Viral
MH  - Humans
MH  - Lung/microbiology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
MH  - Neutralization Tests
MH  - Recurrence
MH  - Salivary Glands/microbiology
MH  - Spleen/microbiology
MH  - *Virus Latency
PMC - PMC2191331
EDAT- 1994/01/01 00:00
MHDA- 1994/01/01 00:01
PMCR- 1994/07/01
CRDT- 1994/01/01 00:00
PHST- 1994/01/01 00:00 [pubmed]
PHST- 1994/01/01 00:01 [medline]
PHST- 1994/01/01 00:00 [entrez]
PHST- 1994/07/01 00:00 [pmc-release]
AID - 94095924 [pii]
AID - 10.1084/jem.179.1.185 [doi]
PST - ppublish
SO  - J Exp Med. 1994 Jan 1;179(1):185-93. doi: 10.1084/jem.179.1.185.