PMID- 8288124
OWN - NLM
STAT- MEDLINE
DCOM- 19940223
LR  - 20190523
IS  - 0890-9369 (Print)
IS  - 0890-9369 (Linking)
VI  - 8
IP  - 1
DP  - 1994 Jan
TI  - odd-paired: a zinc finger pair-rule protein required for the timely activation of 
      engrailed and wingless in Drosophila embryos.
PG  - 105-17
AB  - The pair-rule gene, odd-paired (opa), is essential for parasegmental subdivision 
      of the Drosophila embryo. In addition to its previously defined role in the 
      activation of wingless (wg) in odd parasegments, we find that opa is required for 
      the timely activation of wg in the remaining parasegments and for the timely 
      activation of engrailed (en) in all parasegments. opa encodes a zinc finger 
      protein with fingers homologous to those of the Drosophila segment polarity gene 
      ciD, the human glioblastoma gene GLI and the Caenorhabditis elegans sex 
      determination gene tra-1. Previous work showed that opa activity was essential 
      for the establishment of alternate parasegments, suggesting opa expression or 
      activity would be spatially restricted like other pair-rule genes. Instead, opa 
      mRNA and protein are found throughout all segment primordia. Thus, opa does not 
      act in a spatially restricted manner to establish the position of en and wg 
      expression. Rather, opa must cooperate with other spatially restricted proteins 
      to achieve proper subdivision of the Drosophila embryo.
FAU - Benedyk, M J
AU  - Benedyk MJ
AD  - Rockefeller University, New York, New York 10021-6399.
FAU - Mullen, J R
AU  - Mullen JR
FAU - DiNardo, S
AU  - DiNardo S
LA  - eng
SI  - GENBANK/U04435
GR  - GM-13838/GM/NIGMS NIH HHS/United States
GR  - GM-45747/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genes Dev
JT  - Genes & development
JID - 8711660
RN  - 0 (Drosophila Proteins)
RN  - 0 (En protein, Drosophila)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (Insect Hormones)
RN  - 0 (Opa protein, Drosophila)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Transcription Factors)
RN  - 0 (Wnt1 Protein)
RN  - 0 (wg protein, Drosophila)
SB  - IM
GS  - GLI
GS  - en
GS  - opa
GS  - wg
MH  - Amino Acid Sequence
MH  - Animals
MH  - Cloning, Molecular
MH  - Drosophila/embryology/*genetics
MH  - *Drosophila Proteins
MH  - Female
MH  - Gene Expression Regulation
MH  - *Homeodomain Proteins
MH  - Humans
MH  - Insect Hormones/*genetics
MH  - Male
MH  - Molecular Sequence Data
MH  - Mutation
MH  - Phenotype
MH  - Proto-Oncogene Proteins/*genetics
MH  - RNA, Messenger/biosynthesis
MH  - Restriction Mapping
MH  - Sequence Homology, Amino Acid
MH  - Transcription Factors/*genetics
MH  - Wnt1 Protein
MH  - Zinc Fingers/*genetics
EDAT- 1994/01/01 00:00
MHDA- 1994/01/01 00:01
CRDT- 1994/01/01 00:00
PHST- 1994/01/01 00:00 [pubmed]
PHST- 1994/01/01 00:01 [medline]
PHST- 1994/01/01 00:00 [entrez]
AID - 10.1101/gad.8.1.105 [doi]
PST - ppublish
SO  - Genes Dev. 1994 Jan;8(1):105-17. doi: 10.1101/gad.8.1.105.