PMID- 8288131
OWN - NLM
STAT- MEDLINE
DCOM- 19940223
LR  - 20221207
IS  - 0890-9369 (Print)
IS  - 0890-9369 (Linking)
VI  - 8
IP  - 1
DP  - 1994 Jan
TI  - p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and 
      contact inhibition to cell cycle arrest.
PG  - 9-22
AB  - Cell-cell contact and TGF-beta can arrest the cell cycle in G1. Mv1Lu mink 
      epithelial cells arrested by either mechanism are incapable of assembling active 
      complexes containing the G1 cyclin, cyclin E, and its catalytic subunit, Cdk2. 
      These growth inhibitory signals block Cdk2 activation by raising the threshold 
      level of cyclin E necessary to activate Cdk2. In arrested cells the threshold is 
      set higher than physiological cyclin E levels and is determined by an inhibitor 
      that binds to cyclin E-Cdk2 complexes. A 27-kD protein that binds to and prevents 
      the activation of cyclin E-Cdk2 complexes can be purified from arrested cells but 
      not from proliferating cells, using cyclin E-Cdk2 affinity chromatography. p27 is 
      present in proliferating cells, but it is sequestered and unavailable to interact 
      with cyclin E-Cdk2 complexes. Cyclin D2-Cdk4 complexes bind competitively to and 
      down-regulate the activity of p27 and may thereby act in a pathway that reverses 
      Cdk2 inhibition and enables G1 progression.
FAU - Polyak, K
AU  - Polyak K
AD  - Cell Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New 
      York, New York 10021.
FAU - Kato, J Y
AU  - Kato JY
FAU - Solomon, M J
AU  - Solomon MJ
FAU - Sherr, C J
AU  - Sherr CJ
FAU - Massague, J
AU  - Massague J
FAU - Roberts, J M
AU  - Roberts JM
FAU - Koff, A
AU  - Koff A
LA  - eng
GR  - CA-21765A/CA/NCI NIH HHS/United States
GR  - CA-47064/CA/NCI NIH HHS/United States
GR  - GM47830/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genes Dev
JT  - Genes & development
JID - 8711660
RN  - 0 (Cyclins)
RN  - 0 (Protein Kinase Inhibitors)
RN  - 0 (Proteins)
RN  - 0 (Transforming Growth Factor beta)
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - EC 2.7.11.22 (CDC2-CDC28 Kinases)
RN  - EC 2.7.11.22 (Cyclin-Dependent Kinase 2)
RN  - EC 2.7.11.22 (Cyclin-Dependent Kinases)
RN  - EC 2.7.11.22 (Cyclin-Dependent Kinase-Activating Kinase)
SB  - IM
MH  - Animals
MH  - *CDC2-CDC28 Kinases
MH  - Cell Communication
MH  - *Cell Cycle
MH  - Cell Line
MH  - Cyclin-Dependent Kinase 2
MH  - *Cyclin-Dependent Kinases
MH  - Cyclins/*metabolism
MH  - Mink
MH  - Protein Kinase Inhibitors
MH  - Protein Kinases/*metabolism
MH  - Protein Serine-Threonine Kinases/antagonists & inhibitors
MH  - Protein-Tyrosine Kinases/metabolism
MH  - Proteins/*metabolism
MH  - Signal Transduction
MH  - Transforming Growth Factor beta/*physiology
MH  - Cyclin-Dependent Kinase-Activating Kinase
EDAT- 1994/01/01 00:00
MHDA- 1994/01/01 00:01
CRDT- 1994/01/01 00:00
PHST- 1994/01/01 00:00 [pubmed]
PHST- 1994/01/01 00:01 [medline]
PHST- 1994/01/01 00:00 [entrez]
AID - 10.1101/gad.8.1.9 [doi]
PST - ppublish
SO  - Genes Dev. 1994 Jan;8(1):9-22. doi: 10.1101/gad.8.1.9.