PMID- 8301315
OWN - NLM
STAT- MEDLINE
DCOM- 19940309
LR  - 20190512
IS  - 0022-3069 (Print)
IS  - 0022-3069 (Linking)
VI  - 53
IP  - 1
DP  - 1994 Jan
TI  - The p53 gene and protein in human brain tumors.
PG  - 11-21
AB  - p53 mutation is most likely an integral early step in the formation of a subset 
      of human diffuse, fibrillary astrocytomas, but is not a frequent event in other 
      studied brain tumors. In astrocytomas, p53 mutations are clustered in the 
      conserved regions of the gene and are predominantly single base pair transitions, 
      frequently at CpG dinucleotides. These mutations result in mutant or truncated 
      p53 proteins that lack the transcriptional activating ability to induce G1 
      arrest, DNA repair, apoptosis or differentiation. On the other hand, some 
      astrocytomas without p53 mutations may accumulate wild-type protein, perhaps as a 
      physiological response to DNA damage or deregulated proliferation in the tumor 
      cells. Finally, while data on the p53 gene and protein studies in human brain 
      tumors are accumulating rapidly, the clinical significance of such data remains 
      unclear.
FAU - Louis, D N
AU  - Louis DN
AD  - Department of Pathology (Neuropathology), Massachusetts General Hospital, Boston 
      02114.
LA  - eng
GR  - CA09144/CA/NCI NIH HHS/United States
GR  - CA57683/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - England
TA  - J Neuropathol Exp Neurol
JT  - Journal of neuropathology and experimental neurology
JID - 2985192R
RN  - 0 (Dinucleoside Phosphates)
RN  - 0 (Tumor Suppressor Protein p53)
SB  - IM
GS  - TP53
GS  - p53
MH  - Astrocytoma/genetics
MH  - Base Sequence
MH  - Brain Neoplasms/*genetics/pathology
MH  - Chromosomes, Human, Pair 17
MH  - Dinucleoside Phosphates/analysis
MH  - *Genes, p53
MH  - Humans
MH  - *Mutation
MH  - Tumor Suppressor Protein p53/analysis/*metabolism
RF  - 102
EDAT- 1994/01/01 00:00
MHDA- 1994/01/01 00:01
CRDT- 1994/01/01 00:00
PHST- 1994/01/01 00:00 [pubmed]
PHST- 1994/01/01 00:01 [medline]
PHST- 1994/01/01 00:00 [entrez]
AID - 10.1097/00005072-199401000-00002 [doi]
PST - ppublish
SO  - J Neuropathol Exp Neurol. 1994 Jan;53(1):11-21. doi: 
      10.1097/00005072-199401000-00002.