PMID- 8314084
OWN - NLM
STAT- MEDLINE
DCOM- 19940318
LR  - 20190524
IS  - 0890-9369 (Print)
IS  - 0890-9369 (Linking)
VI  - 8
IP  - 3
DP  - 1994 Feb 1
TI  - Stripe-specific regulation of pair-rule genes by hopscotch, a putative Jak family 
      tyrosine kinase in Drosophila.
PG  - 300-12
AB  - We describe the characterization of the Drosophila gene, hopscotch (hop), which 
      is required maternally for the establishment of the normal array of embryonic 
      segments. In hop embryos, although expression of the gap genes appears normal, 
      there are defects in the expression patterns of the pair-rule genes even-skipped, 
      runt, and fushi tarazu, as well as the segment-polarity genes engrailed and 
      wingless. We demonstrate that the effect of hop on the expression of these genes 
      is stripe-specific. The hop gene encodes a putative nonreceptor tyrosine kinase 
      of the Janus kinase family, based on an internal duplication of the catalytic 
      domain. We present a model in which the Hop tyrosine kinase is involved in the 
      control of pair-rule gene transcription in a stripe-specific manner. Our results 
      provide the first evidence for stripe-specific regulation of pair-rule genes by a 
      tyrosine kinase.
FAU - Binari, R
AU  - Binari R
AD  - Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115.
FAU - Perrimon, N
AU  - Perrimon N
LA  - eng
SI  - GENBANK/L26975
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genes Dev
JT  - Genes & development
JID - 8711660
RN  - 0 (Drosophila Proteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Transcription Factors)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
RN  - EC 2.7.10.2 (Janus Kinase 2)
RN  - EC 2.7.10.2 (Janus Kinases)
RN  - EC 2.7.10.2 (hop protein, Drosophila)
SB  - IM
GS  - hop
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Drosophila Proteins
MH  - Drosophila melanogaster/*embryology/*enzymology/genetics
MH  - Embryo, Nonmammalian/physiology
MH  - Female
MH  - *Gene Expression Regulation, Enzymologic
MH  - *Genes, Insect
MH  - Genes, Lethal
MH  - Janus Kinase 2
MH  - Janus Kinases
MH  - Larva
MH  - Male
MH  - Molecular Sequence Data
MH  - Promoter Regions, Genetic
MH  - Protein-Tyrosine Kinases/chemistry/*genetics/physiology
MH  - *Proto-Oncogene Proteins
MH  - Sequence Analysis, DNA
MH  - Transcription Factors/genetics
MH  - X Chromosome
EDAT- 1994/02/01 00:00
MHDA- 1994/02/01 00:01
CRDT- 1994/02/01 00:00
PHST- 1994/02/01 00:00 [pubmed]
PHST- 1994/02/01 00:01 [medline]
PHST- 1994/02/01 00:00 [entrez]
AID - 10.1101/gad.8.3.300 [doi]
PST - ppublish
SO  - Genes Dev. 1994 Feb 1;8(3):300-12. doi: 10.1101/gad.8.3.300.