PMID- 8345199
OWN - NLM
STAT- MEDLINE
DCOM- 19930908
LR  - 20141120
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 151
IP  - 4
DP  - 1993 Aug 15
TI  - Transforming growth factor-beta suppresses activation and proliferation of 
      microglia in vitro.
PG  - 2150-8
AB  - Transforming growth factor-beta (TGF-beta) has been shown to be produced in the 
      central nervous system (CNS). The functions of TGF-beta, however, remain to be 
      elucidated. We investigated the effects of TGF-beta on the proliferation, 
      activation, and cytokine production of isolated microglia in vitro. TGF-beta 
      dose-dependently suppressed the acid phosphatase activity of and formation of 
      superoxide anion by LPS activated microglia. It also suppressed the 
      IFN-gamma-induced expression of class II MHC Ag- and the production of cytokines, 
      IL-1, IL-6, and TNF-alpha, by these cells. TGF-beta also inhibited the 
      proliferation of microglia that was induced by either GM-CSF or M-CSF. Because 
      various immunoregulatory cytokines are produced in the CNS that serve as 
      autocrine or paracrine mediators it is suggested that TGF-beta could be a 
      negative regulator in the CNS cytokine network. It may play a role in the 
      development of various disease processes in the CNS by inhibiting the function of 
      microglia in inflammation or in immunoregulation.
FAU - Suzumura, A
AU  - Suzumura A
AD  - Department of Neurology, School of Medicine, Fujita Health University, Aichi, 
      Japan.
FAU - Sawada, M
AU  - Sawada M
FAU - Yamamoto, H
AU  - Yamamoto H
FAU - Marunouchi, T
AU  - Marunouchi T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (Cytokines)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (Oligodeoxyribonucleotides)
RN  - 0 (Transforming Growth Factor beta)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Cell Division/drug effects
MH  - Cells, Cultured
MH  - Cytokines/*genetics
MH  - Gene Expression/drug effects
MH  - Genes, MHC Class II
MH  - Histocompatibility Antigens Class II/*genetics
MH  - In Vitro Techniques
MH  - Mice
MH  - Mice, Inbred C3H
MH  - Molecular Sequence Data
MH  - Neuroglia/cytology/*physiology
MH  - Oligodeoxyribonucleotides/chemistry
MH  - Transforming Growth Factor beta/*pharmacology
EDAT- 1993/08/15 00:00
MHDA- 1993/08/15 00:01
CRDT- 1993/08/15 00:00
PHST- 1993/08/15 00:00 [pubmed]
PHST- 1993/08/15 00:01 [medline]
PHST- 1993/08/15 00:00 [entrez]
PST - ppublish
SO  - J Immunol. 1993 Aug 15;151(4):2150-8.